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The chemistry and pharmacology of Edelweiss: a review

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Abstract

Leontopodium nivale ssp. alpinum (syn. Leontopodium alpinum) is a perennial herb commonly known as Edelweiss, which has a long tradition in Alpine countries and adjacent regions as a medicinal plant. This review discusses current knowledge on the traditional uses, chemistry, biological activities and toxicology of this species. Several different classes of compounds such as terpenoids (analogues of sesquiterpenes, bisabolenes), phenylpropanoids (phenolic acids, flavonoids, coumarins, lignans), fatty acids and polyacetylenes were previously isolated from various parts of Edelweiss. Different types of extracts and compounds derived from this plant have been found to possess a broad spectrum of pharmacological activities on the cardiovascular and nervous systems. Furthermore, the plant have known anti-inflammatory, antimicrobial, antioxidant and chemo-protective effects. The observed pharmacological activities as well as toxicological profile of preparations and isolated compounds of Edelweiss support the view that these might be used in the development of agents with therapeutic benefit in various human diseases. Some suggestions for further research on chemical characterization and pharmacological properties are also given in this review.

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References

  • Bhatnagar D, Ehrlich KC, Cleveland TE (2003) Molecular genetic analysis and regulation of aflatoxin biosynthesis. Appl Microbiol Biotechnol 61:83–93

    Article  CAS  PubMed  Google Scholar 

  • Bicchi C, Nano GM, Tira S (1975) n Paraffin components of some gnaphalieae. Planta Med 28:389–391

    Article  CAS  PubMed  Google Scholar 

  • Blascakova M, Poracova J, Mydlar J, Zahatnanska M (2011) Law protected plants of national nature reserve dreveník (hornád basin) in project learning. Acta Hortic 920:167–174

    Article  Google Scholar 

  • Blöch C, Dickoré WB, Samuel R, Stuessy TF (2010) Molecular phylogeny of the edelweiss (Leontopodium, Asteraceae—Gnaphalieae). Edinb J Bot 67:235–264. doi:10.1017/S0960428610000065

    Article  Google Scholar 

  • Cervellati R, Höner K, Furrow SD et al (2001) The Briggs-Rauscher reaction as a test to measure the activity of antioxidants. Helv Chim Acta 84:3533–3547. doi:10.1002/1522-2675(20011219)84:12<3533:AID-HLCA3533>3.0.CO;2-Y

    Article  CAS  Google Scholar 

  • Cervellati R, Renzulli C, Guerra MC, Speroni E (2002) Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. J Agric Food Chem 50:7504–7509. doi:10.1021/jf020578n

    Article  CAS  PubMed  Google Scholar 

  • Chopra I (2013) The 2012 garrod lecture: discovery of antibacterial drugs in the 21st century. J Antimicrob Chemother 68:496–505. doi:10.1093/jac/dks436

    Article  CAS  PubMed  Google Scholar 

  • Cicek SS, Untersulzner C, Schwaiger S, Zidorn C (2012) Caffeoyl-D-glucaric acid derivatives in the genus Gnaphalium (Asteraceae: Gnaphalieae). Rec Nat Prod 6:311–315

    CAS  Google Scholar 

  • Comey N, Hook I, Sheridan H (1992a) Essential oil from normal and hairy roots of Leontopodium alpinum. In: Proceedings of 23rd international symposium on essential oils. Ayr, Scotland

  • Comey N, Hook I, Sheridan H (1992b) Enhancement of anthocyanin production in cell cultures and hairy roots of Leontopodium alpinum. Planta Med 58:A605–A606

    Article  Google Scholar 

  • Comey N, Hook I, Sheridan H et al (1997) Isolation of (S)-(-)-2,3-dihydro-2,6-dimethyl-4H-benzopyran-4-one from roots of Leontopodium alpinum. J Nat Prod 60:148–149. doi:10.1021/np960228t

    Article  CAS  Google Scholar 

  • Costa S, Schwaiger S, Cervellati R et al (2009) In vitro evaluation of the chemoprotective action mechanisms of leontopodic acid against aflatoxin B1 and deoxynivalenol-induced cell damage. J Appl Toxicol 29:7–14. doi:10.1002/jat.1372

    Article  CAS  PubMed  Google Scholar 

  • Costa S, Cervellati R, Speroni E et al (2010) Free radicals and antioxidants in two oxidative-stress cell models exposed to ochratoxin A and amyloid β: Unexpected results. World Mycotoxin J 3:257–261. doi:10.3920/WMJ2010.1221

    Article  CAS  Google Scholar 

  • Daniela L, Alla P, Maurelli R et al (2012) Anti-inflammatory effects of concentrated ethanol extracts of edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells. Mediators Inflamm. doi:10.1155/2012/498373

    PubMed  PubMed Central  Google Scholar 

  • Desbois AP (2012) Potential applications of antimicrobial fatty acids in medicine, agriculture and other industries. Recent Pat Anti-Infect Drug Disc 7:111–122. doi:10.2174/157489112801619728

    Article  CAS  Google Scholar 

  • Dewick PM (2009) Medicinal natural products: a biosynthetic approach, 3rd edn. Wiley, Chichester, UK

    Book  Google Scholar 

  • Dobner MJ, Ellmerer EP, Schwaiger S et al (2003a) New lignan, benzofuran, and sesquiterpene derivatives from the roots of Leontopodium alpinum and L. leontopodioides. Helv Chim Acta 86:733–738. doi:10.1002/hlca.200390072

    Article  CAS  Google Scholar 

  • Dobner MJ, Schwaiger S, Jenewein IH, Stuppner H (2003b) Antibacterial activity of Leontopodium alpinum (Edelweiss). J Ethnopharmacol 89:301–303. doi:10.1016/j.jep.2003.09.004

    Article  PubMed  Google Scholar 

  • Dobner MJ, Sosa S, Schwaiger S et al (2004) Anti-inflammatory activity of Leontopodium alpinum and its constituents. Planta Med 70:502–508. doi:10.1055/s-2004-827148

    Article  CAS  PubMed  Google Scholar 

  • Duwensee K, Schwaiger S, Tancevski I et al (2011) Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein. Atherosclerosis 219:109–115. doi:10.1016/j.atherosclerosis.2011.07.023

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dzau VJ, Braun-Dullaeus RC, Sedding DG (2002) Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat Med 8:1249–1256. doi:10.1038/nm1102-1249

    Article  CAS  PubMed  Google Scholar 

  • Erhardt A (1993) Pollination of the edelweiss, Leontopodium alpinum. Bot J Linn Soc 111:229–240. doi:10.1006/bojl.1993.1016

    Article  Google Scholar 

  • Finkenzeller X (2014) Alpenblumen, 4th edn. Verlag Eugen Ulmer, Stuttgart, Germany

    Google Scholar 

  • Fischer F, Zufferey E, Bourgeois J-M et al (2011) UV-ABC screens of luteolin derivatives compared to edelweiss extract. J Photochem Photobiol B 103:8–15. doi:10.1016/j.jphotobiol.2011.01.005

    Article  CAS  PubMed  Google Scholar 

  • Ganzera M, Greifeneder V, Schwaiger S, Stuppner H (2012) Chemical profiling of Edelweiss (Leontopodium alpinum Cass.) extracts by micellar electrokinetic capillary chromatography. Fitoterapia 83:1680–1686. doi:10.1016/j.fitote.2012.09.023

    Article  CAS  PubMed  Google Scholar 

  • Greuter W (2003) The Euro + Med treatment of Gnaphalieae and Inuleae (Compositae)—generic concepts and required new names. Willdenowia 33:239–244. doi:10.3372/wi.33.33202

    Article  Google Scholar 

  • Grey AI, Hook IL, James P, Sheridan H (1999) Sesquiterpenes from Leontopodium alpinum. Phytochemistry 50:1057–1060. doi:10.1016/S0031-9422(98)00625-6

    Article  Google Scholar 

  • Halliwell B, Gutteridge JM (2007) Free radicals in biology and medicine, 4th edn. Oxford University Press, Oxford, UK

    Google Scholar 

  • Handl-Mazzetti H (1928) Systematische monographie der gattung Leontopodium. Beih Zum Bot Cent 44:1–178

    Google Scholar 

  • Hennessy D, Hook I, Sheridan H, McGee A (1989) Hydroxycinnamic acid esters from cell suspension cultures and plants of Leontopodium alpinum. Phytochemistry 28:489–490

    Article  CAS  Google Scholar 

  • Hook ILI (1993) Leontopodium alpinum Cass. (edelweiss): in vitro culture, micropropagation, and the production of secondary metabolites. In: Bajaj YPS (ed) Biotechnology in agriculture and forestry 21: medicinal and aromatic plants IV. Springer Verlag, Berlin, Germany, pp 217–232

    Google Scholar 

  • Hook I (1994) Secondary metabolites in hairy root cultures of Leontopodium alpinum Cass. (Edelweiss). Plant Cell Tissue Organ Cult 38:321–326. doi:10.1007/BF00033892

    Article  CAS  Google Scholar 

  • Hörandl E, Dobeš C, Suda J et al (2011) Apomixis is not prevalent in subnival to nival plants of the European Alps. Ann Bot 108:381–390. doi:10.1093/aob/mcr142

    Article  PubMed  PubMed Central  Google Scholar 

  • Hornick A, Schwaiger S, Rollinger JM et al (2008) Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: Brain ACh increasing and memory improving properties. Biochem Pharmacol 76:236–248. doi:10.1016/j.bcp.2008.04.015

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Keller R, Vittoz P (2015) Clonal growth and demography of a hemicryptophyte alpine plant: Leontopodium alpinum Cassini. Alp Bot 125:31–40. doi:10.1007/s00035-014-0142-y

    Article  Google Scholar 

  • Khela S (2013) Leontopodium alpinum. The IUCN Red List of Threatened Species 2013: e.T202984A2758405. http://dx.doi.org/10.2305/IUCN.UK.2013-2.RLTS.T202984A2758405.en. Accessed 10 Apr 2015

  • Kitahara T, Koyama N, Matsuda J et al (2004) Antimicrobial activity of saturated fatty acids and fatty amines against methicillin-resistant Staphylococcus aureus. Biol Pharm Bull 27:1321–1326. doi:10.1248/bpb.27.1321

    Article  CAS  PubMed  Google Scholar 

  • Koleva II, Niederländer HAG, Van Beek TA (2001) Application of ABTS radical cation for selective on-line detection of radical scavengers in HPLC eluates. Anal Chem 73:3373–3381. doi:10.1021/ac0013610

    Article  CAS  PubMed  Google Scholar 

  • Lee D-H, Lee J-H, Choi B-H (2011) Isolation and characterization of 10 microsatellite loci from Korean Leontopodium japonicum (Asteraceae). Am J Bot 98:e183–e184. doi:10.3732/ajb.1100065

    Article  CAS  PubMed  Google Scholar 

  • Matthioli PA (1931) Herbář - jinak bylinář velmi užitečný, překlad Tadeáš Hájek z Hájku. Nakladatel Bedřich Kočí, Prague, Czech Republic

  • Maugini E (1962) Morfologia fiorale, embriologia ed embriogenesi in Leontopodium alpinum Cass. var. typicum Fiori e Paoletti. G Bot Ital 69:1–12

    Article  Google Scholar 

  • Messner B, Kern J, Wiedemann D et al (2013) 5-Methoxyleoligin, a lignan from Edelweiss, stimulates CYP26B1-dependent angiogenesis in vitro and induces arteriogenesis in infarcted rat hearts in vivo. PLoS One. doi:10.1371/journal.pone.0058342

    Google Scholar 

  • Neblea M, Marian M, Duţǎ M (2012) Medicinal plant diversity in the flora of the west part of Bucegi Mountains (Romania). Acta Hortic 955:41–50

    Article  Google Scholar 

  • Nussbaumer S, Bonnabry P, Veuthey J-L, Fleury-Souverain S (2011) Analysis of anticancer drugs: a review. Talanta 85:2265–2289

    Article  CAS  PubMed  Google Scholar 

  • Piccini A, Russo C, Gliozzi A et al (2005) β-amyloid is different in normal aging and in Alzheimer disease. J Biol Chem 280:34186–34192

    Article  CAS  PubMed  Google Scholar 

  • Re R, Pellegrini N, Proteggente A et al (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26:1231–1237. doi:10.1016/S0891-5849(98)00315-3

    Article  CAS  PubMed  Google Scholar 

  • Reisinger U, Schwaiger S, Zeller I et al (2009) Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts. Cardiovasc Res 82:542–549. doi:10.1093/cvr/cvp059

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ritsch A, Scharnagl H, Eller P et al (2010) Cholesteryl ester transfer protein and mortality in patients undergoing coronary angiography: the ludwigshafen risk and cardiovascular health study. Circulation 121:366–374. doi:10.1161/CIRCULATIONAHA.109.875013

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Safer S, Cicek SS, Pieri V et al (2011a) Metabolic fingerprinting of Leontopodium species (Asteraceae) by means of 1H NMR and HPLC-ESI-MS. Phytochemistry 72:1379–1389. doi:10.1016/j.phytochem.2011.04.006

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Safer S, Tremetsberger K, Guo Y-P et al (2011b) Phylogenetic relationships in the genus Leontopodium (Asteraceae: Gnaphalieae) based on AFLP data. Bot J Linn Soc 165:364–377. doi:10.1111/j.1095-8339.2011.01117.x

    Article  PubMed  PubMed Central  Google Scholar 

  • Schwaiger S, Dobner MJ, Odonchimeg B et al (2002) Phytochemical profile of Leontopodium alpinum Cass in comparison to other Asian Leontopodium species. Rev Fitoter 2:241

    Google Scholar 

  • Schwaiger S, Adams M, Seger C et al (2004) New constituents of Leontopodium alpinum and their in vitro leukotriene biosynthesis inhibitory activity. Planta Med 70:978–985. doi:10.1055/s-2004-832625

    Article  CAS  PubMed  Google Scholar 

  • Schwaiger S, Cervellati R, Seger C et al (2005) Leontopodic acid—a novel highly substituted glucaric acid derivative from Edelweiss (Leontopodium alpinum Cass.) and its antioxidative and DNA protecting properties. Tetrahedron 61:4621–4630. doi:10.1016/j.tet.2005.03.002

    Article  CAS  Google Scholar 

  • Schwaiger S, Seger C, Wiesbauer B et al (2006) Development of an HPLC-PAD-MS assay for the identification and quantification of major phenolic edelweiss (Leontopodium alpium Cass.) constituents. Phytochem Anal 17:291–298

    Article  CAS  PubMed  Google Scholar 

  • Siljak S, Cartier D, Gorenflot R (1974) Introduction a l’etude de Leontopodium alpinum Cass.: variabilite morphologique et nombre chromosomique dans les populations naturelles. Comptes Rendus Hebd Séances Académie Sci 278:2905–2908

    Google Scholar 

  • Speroni E, Schwaiger S, Egger P et al (2006) In vivo efficacy of different extracts of Edelweiss (Leontopodium alpinum Cass.) in animal models. J Ethnopharmacol 105:421–426. doi:10.1016/j.jep.2005.11.019

    Article  PubMed  Google Scholar 

  • Stuppner H, Ellmerer EP, Ongania K-H, Dobner M (2002) Bisabolane derivatives from Leontopodium alpinum. Helv Chim Acta 85:2982–2989. doi:10.1002/1522-2675(200209)85:9<2982:AID-HLCA2982>3.0.CO;2-H

    Article  CAS  Google Scholar 

  • Sugar I (1971) Ucka - novo nalaziste runolista (Leontopodium alpinum Cass. var. krasense (Derb.) Hay.) u Hrvatskoj. (Le mont Ucka une nouvelle localite de Leontopodium alpinum Cass. var. krasense (Derg.) Hay en Croatie.). Acta Bot Croat 30:153–156

    Google Scholar 

  • Tabernaemontanus JT (1993) Das Ander Buch von Kreutern (1582). In: Bauhin H (ed) D. Jacobi theodori tabernaemontani neu vollkommen kraeuter-buch. Verlag Kölbl, Grünwald bei München, pp 779–782

  • Tira S, Galeffi C, Di Modica G (1970) Flavonoids of Gnaphalieae: Leontopodium alpinum cass. Experientia 26:1192. doi:10.1007/BF01897956

    Article  CAS  PubMed  Google Scholar 

  • Trejgell A, Tretyn A (2010) Micropropagation in in vitro culture efficiency of selected protected species Asteraceae. Biotechnologia 3:202–209

    Google Scholar 

  • Wawrosch C, Schwaiger S, Stuppner H, Kopp B (2014) Lignan formation in hairy root cultures of Edelweiss (Leontopodium nivale ssp. alpinum (Cass.) Greuter). Fitoterapia 97:219–223. doi:10.1016/j.fitote.2014.06.008

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yamamoto A, Matsuzawa Y, Yokoyama S et al (1986) Effects of probucol on xanthomata regression in familial hypercholesterolemia. Am J Cardiol 57:H29–H35. doi:10.1016/0002-9149(86)90434-0

    Article  Google Scholar 

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Acknowledgments

We would like to express our gratitude to Thomas Lichtenberg for providing us with the picture of Edelweiss in its natural habitat. We are also very grateful to Ludvík Bortl who read the manuscript and provided critical comments. Finally, great appreciation goes to Micheal Ua Seaghdha for his final linguistic revision of the English text.

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  1. The Department of Quality of Agricultural Products, The Faculty of Agrobiology, Food and Natural Resources, The Czech University of Life Sciences Prague, Kamycka 129, 165 21, Prague 6 – Suchdol, Czech Republic

    Jan Tauchen

  2. The Department of Crop Sciences and Agroforestry, The Faculty of Tropical AgriSciences, The Czech University of Life Sciences Prague, Kamycka 129, 165 21, Prague 6 – Suchdol, Czech Republic

    Ladislav Kokoska

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Tauchen, J., Kokoska, L. The chemistry and pharmacology of Edelweiss: a review. Phytochem Rev 16, 295–308 (2017). https://doi.org/10.1007/s11101-016-9474-0

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