Advertisement

Phytochemistry Reviews

, Volume 14, Issue 4, pp 567–575 | Cite as

Comparative efficacy of Ocimum sanctum L. and Ocimum basilicum L. essential oils against amyloid beta (1–42)-induced anxiety and depression in laboratory rats

  • Veronica Gradinariu
  • Oana Cioanca
  • Lucian Hritcu
  • Adriana Trifan
  • Elvira Gille
  • Monica Hancianu
Article

Abstract

The present study analyzed the possible anxiolytic and antidepressant proprieties of inhaled basil essential oils extracted from Ocimum sanctum L. (Os) and Ocimum basilicum L. (Ob) in β-amyloid (1–42) rat model of Alzheimer’s disease. The anxiolytic- and antidepressant-like effects of inhaled basil essential oils were studied by means of in vivo (elevated plus-maze and forced swimming tests) approaches. The β-amyloid (1–42)-treated rats exhibited the following: decrease of the exploratory activity (number of crossing), the percentage of the time spent and the number of entries in the open arm within elevated plus-maze test and increase of the swimming time and decrease of the immobility time within forced swimming test. The chemical composition varied from one sample to another. The main compounds found in both samples were linalool (31 %–Ob, 19 %–Os), camphor, β-elemene, α-bergamotene and bornyl-acetate, estragole (15.57 and 7.59 %, respectively), eugenol (2.64 and 1.39 %, respectively) and 1,8-cineole (3.29 and 3.90 %, respectively). As a result, exposure to basil essential oils significantly improved the behavior of the animals, suggesting anxiolytic- and antidepressant-like effects. Our results suggest that multiple exposures to basil essential oils can be useful as a mean to counteract anxiety and depression in Alzheimer’s disease conditions.

Keywords

Basil essential oil β-amyloid (1–42) peptide Anxiety Depression Alzheimer’s disease 

Notes

Acknowledgments

This work was supported by POSDRU/159/1.5/S/133377, University of Medicine and Pharmacy “Gr. T. Popa” Iasi, Romania.

Conflict of interest

The authors declare that they have no potential conflicts of interest to disclose.

References

  1. Adams RP (2007) Identification of essential oil by gas chromatography/mass spectroscopy. Allured Publishing Corporation, Carol StreamGoogle Scholar
  2. Aydemir T, Becerik S (2011) Phenolic content and antioxidant activity of different extracts from Ocimum basilicum, Apium graveolens and Lepidium sativum seeds. J Food Biochem 35:62–79CrossRefGoogle Scholar
  3. Bandyopadhyay S, Rogers J (2014) Alzheimer’s disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis. Biochem Pharmacol 88:486–494PubMedCentralPubMedCrossRefGoogle Scholar
  4. Berić T, Nikolić B, Stanojević J, Vuković-Gačić B, Knežević-Vukčević J (2008) Protective effect of basil (Ocimum basilicum L.) against oxidative DNA damage and mutagenesis. Food Chem Toxicol 46:724–732PubMedCrossRefGoogle Scholar
  5. Blainski A, Piccolo VK, Mello JCP, de Oliveira RMW (2010) Dual effects of crude extracts obtained from Petiveria alliacea L. (Phytolaccaceae) on experimental anxiety in mice. J Ethnopharmacol 128:541–544PubMedCrossRefGoogle Scholar
  6. Campos M, Fernandes E, Ferreira J, Santos AS, Calixto J (2005) Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms. J Psychopharmacol (Berl) 182:45–53CrossRefGoogle Scholar
  7. Caraci F, Copani A, Nicoletti F, Drago F (2010) Depression and Alzheimer’s disease: neurobiological links and common pharmacological targets. Eur J Pharmacol 626:64–71PubMedCrossRefGoogle Scholar
  8. Carović-Stanko K, Orlić S, Politeo O, Strikić F, Kolak I, Milos M, Satovic Z (2010) Composition and antibacterial activities of essential oils of seven Ocimum taxa. Food Chem 119:196–201CrossRefGoogle Scholar
  9. Chaiyana W, Okonogi S (2012) Inhibition of cholinesterase by essential oil from food plant. Phytomedicine 19:836–839PubMedCrossRefGoogle Scholar
  10. Cioanca O, Hritcu L, Mihasan M, Trifan A, Hancianu M (2014) Inhalation of basil essential oil increased anxiolytic–antidepressant-like behaviors and decreased oxidative status in β-amyloid (1–42) rat model of Alzheimer’s disease. Physiol Behav 131:68–74PubMedCrossRefGoogle Scholar
  11. Colaianna M, Tucci P, Zotti M, Morgese MG, Schiavone S, Govoni S, Cuomo V, Trabace L (2010) Soluble βamyloid1-42: a critical player in producing behavioural and biochemical changes evoking depressive-related state? Br J Pharmacol 159:1704–1715PubMedCentralPubMedCrossRefGoogle Scholar
  12. Emamghoreishi M, Khasaki M, Aazam MF (2005) Coriandrum sativum: evaluation of its anxiolytic effect in the elevated plus-maze. J Ethnopharmacol 96:365–370PubMedCrossRefGoogle Scholar
  13. Felsenstein K, Candelario K, Steindler D, Borchelt D (2014) Regenerative medicine in Alzheimer’s disease. Transl Res 163:432–438PubMedCentralPubMedCrossRefGoogle Scholar
  14. Ferretti L, McCurry S, Logsdon R, Gibbons L, Teri L (2001) Anxiety and Alzheimer’s disease. J Geriatr Psychiatry Neurol 14:52–58PubMedCrossRefGoogle Scholar
  15. Geetha RK, Vasudevan DM (2004) Inhibition of lipid peroxidation by botanical extracts of Ocimum sanctum: in vivo and in vitro studies. Life Sci 76:21–28PubMedCrossRefGoogle Scholar
  16. Gradinariu V, Cioanca O, Gille E, Aprotosoaie A, Hritcu L, Hancianu M (2013a) The chemical profile of basil bio-varieties and its implication on the biological activity. Farmacia 61:632–639Google Scholar
  17. Gradinariu V, Cioanca O, Hritcu L, Hancianu M (2013b) Basil bio-varieties cutivated in Romania and the chemical profile of the essential oil. Advances in Biotechnology–SGEM 2013. In: Proceedings 113–120Google Scholar
  18. Hanumanthachar I, Parle M (2006) Evaluation of nootropic potential of Ocimum sanctum. Indian J Exp Biol 40:133–136Google Scholar
  19. Hayashi Y, Sogabe S, Hattori Y, Tanaka J (2012) Anxiolytic and hypnotic effects in mice of roasted coffee bean essential compounds. Neurosci Lett 531:166–169PubMedCrossRefGoogle Scholar
  20. Hwang TJ, Masterman DL, Ortiz F, Fairbanks LA, Cummings JL (2004) Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms. Alzheimer Dis Assoc Disord 18:17–21PubMedCrossRefGoogle Scholar
  21. Jesse CR, Bortolatto CF, Savegnago L, Rocha JBT, Nogueira CW (2008) Involvement of l-arginine–nitric oxide–cyclic guanosine monophosphate pathway in the antidepressant-like effect of tramadol in the rat forced swimming test. Prog Neuropsychopharmacol Biol Psychiatry 32:1838–1843PubMedCrossRefGoogle Scholar
  22. Khodagholi F, Ashabi G (2013) Dietary supplimentation with Salvia sahendica attenuates memory deficits, modulates CREB and its down-stream molecules and decreases apoptosis in amyloid β-injected rats. Behav Brain Res 241:62–69PubMedCrossRefGoogle Scholar
  23. Krishnan S, Rani P (2014) Evaluation of selenium, redox status and their association with plasma amyloid/tau in Alzheimer’s disease. Biol Trace Elem Res 158:158–165PubMedCrossRefGoogle Scholar
  24. Laursen SE, Belknap JK (1986) Intracerebroventricular injections in mice. Some methodological refinements. J Pharmacol Methods 16:355–357PubMedCrossRefGoogle Scholar
  25. Linck VM, da Silva AL, Figueiró M, Caramão EB, Moreno PRH, Elisabetsky E (2010) Effects of inhaled linalool in anxiety, social interaction and aggressive behavior in mice. Phytomedicine 17:679–683PubMedCrossRefGoogle Scholar
  26. Lippa C, Nee L, Mori H, George-Hyslop PHS (1998) Aβ-42 deposition precedes other changes in PS-1 AD. Lancet 352:1117–1118PubMedCrossRefGoogle Scholar
  27. Lok K, Zhao H, Zhang C, He N, Shen H, Wang Z, Zhao W, Yin M (2013) Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer’s disease. J Neurosci 335:145–154Google Scholar
  28. Mansouri MT, Soltani M, Naghizadeh B, Farbood Y, Mashak A, Sarkaki A (2014) A possible mechanism for the anxiolytic-like effect of gallic acid in the rat elevated plus maze. Pharmacol Biochem Behav 117:40–46PubMedCrossRefGoogle Scholar
  29. Navarro-Yepes J, Zavala-Flores L, Anandhan A, Wang F, Skotak M, Chandra N, Li M, Pappa A, Martinez-Fong D, Del Razo LM, Quintanilla-Vega B, Franco R (2014) Antioxidant gene therapy against neuronal cell death. Pharmacol Ther 142:206–230PubMedCentralPubMedCrossRefGoogle Scholar
  30. Oboh G (2008) Antioxidative potential of Ocimum gratissimum and Ocimum canum leaf polyphenols and protective effects on some pro-oxidants induces lipid peroxidation in rat brain: an in vitro study. Am J Food Technol 3:325–334CrossRefGoogle Scholar
  31. Paxinos G, Watson C (2005) The rat brain in stereotaxic coordinates. Academic Press, Elsevier, San DiegoGoogle Scholar
  32. Puzzo D, Privitera L, Fa M, Staniszewski A, Hashimoto G, Aziz F, Sakurai M, Ribe EM, Troy CM, Mercken M, Jung SS, Palmeri A, Arancio O (2011) Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory. Ann Neurol 69:819–830PubMedCentralPubMedCrossRefGoogle Scholar
  33. Rodgers RJ, Dalvi A (1997) Anxiety, defence and the elevated plus-maze. Neurosci Biobehav Rev 21:801–810PubMedCrossRefGoogle Scholar
  34. Rosenblum WI (2014) Why Alzheimer trials fail: removing soluble oligomeric β amyloid is essential, inconsistent, and difficult. Neurobiol Aging 35:969–974PubMedCrossRefGoogle Scholar
  35. Samson J, Sheela Devi R, Ravindran R, Senthilvelan M (2006) Biogenic amine changes in brain regions and attenuating action of Ocimum sanctumin noise exposure. Pharmacol Biochem Behav 83:67–75PubMedCrossRefGoogle Scholar
  36. Samson J, Sheeladevi R, Ravindran R (2007) Oxidative stress in brain and antioxidant activity of Ocimum sanctum in noise exposure. NeuroToxicology 28:679–685PubMedCrossRefGoogle Scholar
  37. Seignourel PJ, Kunik ME, Snow L, Wilson N, Stanley M (2008) Anxiety in dementia: a critical review. Clin Psychol Rev 28:1071–1082PubMedCentralPubMedCrossRefGoogle Scholar
  38. Tolardo R, Zetterman L, Bitencourtt DR, Mora TC, de Oliveira FL, Biavatti MW, Amoah SKS, Bürger C, de Souza MM (2010) Evaluation of behavioral and pharmacological effects of Hedyosmum brasiliense and isolated sesquiterpene lactones in rodents. J Ethnopharmacol 128:63–70PubMedCrossRefGoogle Scholar
  39. Wuwongse S, Chang RC-C, Law ACK (2010) The putative neurodegenerative links between depression and Alzheimer’s disease. Prog Neurobiol 91:362–375PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Veronica Gradinariu
    • 1
  • Oana Cioanca
    • 1
  • Lucian Hritcu
    • 2
  • Adriana Trifan
    • 1
  • Elvira Gille
    • 3
  • Monica Hancianu
    • 1
  1. 1.Department of Pharmacognosy, Faculty of PharmacyUniversity of Medicine and Pharmacy „Gr. T. Popa” IaşiIasiRomania
  2. 2.Department of Biology, Faculty of BiologyAlexandru Ioan Cuza University of IasiIasiRomania
  3. 3.“Stejarul” Biological Research CentreNational Institute of R&D for Biological SciencesPiatra NeamtRomania

Personalised recommendations