Comparative efficacy of Ocimum sanctum L. and Ocimum basilicum L. essential oils against amyloid beta (1–42)-induced anxiety and depression in laboratory rats
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The present study analyzed the possible anxiolytic and antidepressant proprieties of inhaled basil essential oils extracted from Ocimum sanctum L. (Os) and Ocimum basilicum L. (Ob) in β-amyloid (1–42) rat model of Alzheimer’s disease. The anxiolytic- and antidepressant-like effects of inhaled basil essential oils were studied by means of in vivo (elevated plus-maze and forced swimming tests) approaches. The β-amyloid (1–42)-treated rats exhibited the following: decrease of the exploratory activity (number of crossing), the percentage of the time spent and the number of entries in the open arm within elevated plus-maze test and increase of the swimming time and decrease of the immobility time within forced swimming test. The chemical composition varied from one sample to another. The main compounds found in both samples were linalool (31 %–Ob, 19 %–Os), camphor, β-elemene, α-bergamotene and bornyl-acetate, estragole (15.57 and 7.59 %, respectively), eugenol (2.64 and 1.39 %, respectively) and 1,8-cineole (3.29 and 3.90 %, respectively). As a result, exposure to basil essential oils significantly improved the behavior of the animals, suggesting anxiolytic- and antidepressant-like effects. Our results suggest that multiple exposures to basil essential oils can be useful as a mean to counteract anxiety and depression in Alzheimer’s disease conditions.
KeywordsBasil essential oil β-amyloid (1–42) peptide Anxiety Depression Alzheimer’s disease
This work was supported by POSDRU/159/1.5/S/133377, University of Medicine and Pharmacy “Gr. T. Popa” Iasi, Romania.
Conflict of interest
The authors declare that they have no potential conflicts of interest to disclose.
- Adams RP (2007) Identification of essential oil by gas chromatography/mass spectroscopy. Allured Publishing Corporation, Carol StreamGoogle Scholar
- Gradinariu V, Cioanca O, Gille E, Aprotosoaie A, Hritcu L, Hancianu M (2013a) The chemical profile of basil bio-varieties and its implication on the biological activity. Farmacia 61:632–639Google Scholar
- Gradinariu V, Cioanca O, Hritcu L, Hancianu M (2013b) Basil bio-varieties cutivated in Romania and the chemical profile of the essential oil. Advances in Biotechnology–SGEM 2013. In: Proceedings 113–120Google Scholar
- Hanumanthachar I, Parle M (2006) Evaluation of nootropic potential of Ocimum sanctum. Indian J Exp Biol 40:133–136Google Scholar
- Jesse CR, Bortolatto CF, Savegnago L, Rocha JBT, Nogueira CW (2008) Involvement of l-arginine–nitric oxide–cyclic guanosine monophosphate pathway in the antidepressant-like effect of tramadol in the rat forced swimming test. Prog Neuropsychopharmacol Biol Psychiatry 32:1838–1843PubMedCrossRefGoogle Scholar
- Lok K, Zhao H, Zhang C, He N, Shen H, Wang Z, Zhao W, Yin M (2013) Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer’s disease. J Neurosci 335:145–154Google Scholar
- Paxinos G, Watson C (2005) The rat brain in stereotaxic coordinates. Academic Press, Elsevier, San DiegoGoogle Scholar