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Treasure from garden: chemical profiling, pharmacology and biotechnology of mulleins

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Abstract

The genus Verbascum (mulleins), belonging to the family Scrophulariaceae, comprises about 360 species of flowering plants. The leaves, flowers and whole aerial parts of Verbascum spp. have been widely used in traditional medicine for the treatment of respiratory and inflammatory disorders and also display powerful wound healing activity. Verbascum species are found to accumulate several groups of bioactive molecules, therefore they might be utilized as attractive sources of new (drug) leads. The present review attempts to provide an up-to-date comprehensive overview on phytochemical and pharmacological aspects of Verbacum spp. research along with some successful examples of growing (and transforming) mulleins in vitro.

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Authors and Affiliations

  1. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., bl.9, 1113, Sofia, Bulgaria

    Kalina I. Alipieva & Emanuela P. Kostadinova

  2. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330, Ankara, Turkey

    Ilkay Erdogan Orhan

  3. Department of Pharmaceutical Botany, Faculty of Pharmacy, Hacettepe University, 06100, Ankara, Turkey

    I. Irem Tatli Cankaya

  4. The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Plovdiv, Bulgaria

    Milen I. Georgiev

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  1. Kalina I. Alipieva
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  2. Ilkay Erdogan Orhan
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  3. I. Irem Tatli Cankaya
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  4. Emanuela P. Kostadinova
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  5. Milen I. Georgiev
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Correspondence to Kalina I. Alipieva.

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Alipieva, K.I., Orhan, I.E., Cankaya, I.I.T. et al. Treasure from garden: chemical profiling, pharmacology and biotechnology of mulleins. Phytochem Rev 13, 417–444 (2014). https://doi.org/10.1007/s11101-014-9361-5

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