Phytochemistry Reviews

, Volume 11, Issue 4, pp 567–616 | Cite as

The therapeutic lead potential of metabolites obtained from natural sources for the treatment of peptic ulcer

  • Luiz Carlos Klein-Júnior
  • José Roberto Santin
  • Rivaldo Niero
  • Sérgio Faloni de Andrade
  • Valdir Cechinel-Filho


For over a century, ulcer has been a major cause of morbidity and mortality. Its treatment has progressed from vagotomy to proton pump inhibitors. However, the drugs used produce many adverse effects and are less effective than they ought to be. Therefore, there is a growing interest in alternative therapies and the use of natural products. This review emphasizes recent studies involving naturally occurring antiulcer metabolites, categorized according to their chemical structure. Both terrestrial and marine sources are included. More than a hundred and fifty different compounds are presented, and where possible, their main mechanisms of action are summarized. Considering that Helicobacter pylori is an important causal factor in the pathogenesis of ulcer disease, an overview of some natural compounds with anti-H. pylori activity is presented.


Ulcer Secondary metabolites Gastroprotection 



The authors are grateful to CNPq, FAPESC, and ProPPEC/UNIVALI for their financial support. They also thank all the authors who have participated in the articles cited in the present work.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Luiz Carlos Klein-Júnior
    • 1
  • José Roberto Santin
    • 1
  • Rivaldo Niero
    • 1
  • Sérgio Faloni de Andrade
    • 1
  • Valdir Cechinel-Filho
    • 1
  1. 1.Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-FarmacêuticasUniversidade do Vale do Itajaí, UNIVALIItajaíBrazil

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