Cubitane: a rare diterpenoid skeleton
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- Wefer, J., Simon, K. & Lindel, T. Phytochem Rev (2013) 12: 95. doi:10.1007/s11101-012-9257-1
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There are only 15 diterpenoids known sharing the rare cubitane skeleton (1,3-diisopropyl-6,10-dimethylcyclododecane, Fig. 1) named after the natural product (+)-cubitene ((+)-1) from the termite Cubitermes umbratus. Cubitane-type diterpenoids (“cubitanoids”) have since then been isolated from gorgonian corals and there are reports that cubitene also occurs in plants. The twelve-membered ring of the cubitanoids is an interesting feature for which we have developed a novel synthesis involving bicyclic precursors. In this review, we discuss the state-of-research regarding isolation, structure elucidation, biological activity, biosynthesis, and total synthesis of cubitane-type diterpenoids.
KeywordsDiterpenoids Total synthesis Structure elucidation Cubitane
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