Chemistry and Pharmacology of Gynostemma pentaphyllum

Abstract

In traditional Chinese medicine, Gynostemma pentaphyllum (Thunb.) Makino is a herbal drug of extreme versatility and has been extensively researched in China. The dammarane saponins isolated from Gynostemma pentaphyllum, namely gypenosides or gynosaponins, are believed to be the active components responsible for its various biological activities and reported clinical effects. This review attempts to encompass the available literature on Gynostemma pentaphyllum, from its cultivation to the isolation of its chemical entities and a summary of its diverse pharmacological properties attributed to its gypenoside content. Other aspects such as toxicology and pharmacokinetics are also discussed. In vitro and in vivo evidence suggests that Gynostemma pentaphyllum may complement the popular herbal medicine, Panax ginseng, as it also contains a high ginsenoside content and exhibits similar biological activities.

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Abbreviations

ara:

arabinose

G. pentaphyllum :

Gynostemma pentaphyllum

glu:

glucose

i.g.:

intragastric

i.m.:

intramuscular

i.p.:

intraperitoneal

i.v.:

intravenous

LD50:

mean lethal dosage

lyx:

lyxose

rha:

rhamnose

s.c.:

subcutaneous

xyl:

xylose

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Correspondence to Basil D. Roufogalis.

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Razmovski-Naumovski, V., Huang, T.H., Tran, V.H. et al. Chemistry and Pharmacology of Gynostemma pentaphyllum. Phytochem Rev 4, 197–219 (2005). https://doi.org/10.1007/s11101-005-3754-4

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Key words

  • dammarane
  • gynosaponin
  • gynoside
  • Gynostemma pentaphyllum
  • gypenoside
  • herbal medicine
  • saponin
  • sterol