Abstract
Tribulus terrestris is a valuable herb known for its application in the folk medicine in many parts of the world. Furostanol and spirostanol saponins of tigogenin, neotigogenin, gitogenin, neogitogenin, hecogenin, neohecogenin, diosgenin, chlorogenin, ruscogenin and sarsasapogenin type are frequently found in this plant. Four sulphated saponins of tigogenin and diosgenin type are also isolated. Extracts and steroidal saponins have been found to possess various pharmacological activities. Preparations based on the saponin fraction of T. terrestris are used for treatment of infertility and libido disorders in men and women, as well as for treatment of cardiac diseases. Food supplements containing T. terrestris extracts are on sale in USA and Europe with claim of a general stimulating action.
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Abbreviations
- Au:
-
Australia
- Az:
-
Azerbeidjan
- Bg:
-
Bulgaria
- Ch:
-
China
- In:
-
India
- M:
-
Moldova
- R:
-
Romania
- SA:
-
South Africa
- T:
-
Turkey
References
PG Adaikan K Gauthman RN Prasad SC Ng (2000) ArticleTitleProerectile pharmacological effects of Tribulus terrestris on the rabit corpus cavernosum Ann. Acad. Med. Singapore 29 22–26 Occurrence Handle10748960 Occurrence Handle1:STN:280:DC%2BD3c3ht1Cnug%3D%3D
PG Adaikan K Gauthman RNV Prasad (2001) ArticleTitleHistory of herbal medicine with an insight on the pharmacological properties of Tribulus terrestris The Aging Male 4 163–169
A Adimoelja (2000) ArticleTitlePhytochemicals and the breakthrough of of traditional herb in the management of sexual disfunction Int. J. Androl. 23 82–84 Occurrence Handle10.1046/j.1365-2605.2000.00020.x Occurrence Handle10849504 Occurrence Handle1:CAS:528:DC%2BD3cXktlyhtbw%3D
A Adimoelja PG Adaikan (1997) ArticleTitleProtodioscin from herbal plant Tribulus terrestris L. improves the male sexual functions, probably via DHEA Int. J. Impotence Res. 9 1–15
PK Agrawal DC Jain RK Gupta RS Takur (1985) ArticleTitleCarbon-13 NMR spectroscopy of steroidal sapogenins and steroidal saponins Phytochemistry 24 2479–2496 Occurrence Handle10.1016/S0031-9422(00)80653-6 Occurrence Handle1:CAS:528:DyaL28XkvVWntw%3D%3D
PK Agrawal (2004) ArticleTitleSpectral assignment and reference data dependence of 1H NMR chemical shifts of geminal protons of glycosyloxy methylene (H2-26) on the orientation of the 27-methyl group of furostane-type steroidal saponins Magn. Reson. Chem. 42 990–993 Occurrence Handle10.1002/mrc.1474 Occurrence Handle15386548 Occurrence Handle1:CAS:528:DC%2BD2cXpvVygs7g%3D
NA Ali WD Julich C Kusnick U Lindequist (2001) ArticleTitleScreening of Yemeni medicinal plants for antibacterial and cytotoxic activities J. Ethnopharmacol. 74 173–9 Occurrence Handle10.1016/S0378-8741(00)00364-0 Occurrence Handle11167035 Occurrence Handle1:STN:280:DC%2BD3M7ls12qtg%3D%3D
R Anand GK Patnaik DK Kulshreshtha BN Dhawan (1994) ArticleTitleActivity of certain fractions of Tribulus terrestris fruits against experimentally induced urolithiasis in rats Indian J. Exp. Biol. 32 548–552 Occurrence Handle7959935 Occurrence Handle1:STN:280:ByqD2cfls1A%3D
HB Arcasoy A Erenmemisoglu Y Tekol S Kurucu M Kartal (1998) ArticleTitleEffect of Tribulus terrestris L. saponin mixture on smooth muscle preparations: a preliminary study Boll. Chim. Farm. 137 473–475 Occurrence Handle10077881 Occurrence Handle1:CAS:528:DyaK1MXisFyhurc%3D
KM Arsyad (1996) ArticleTitleEffect of protodioscin on the quantity and quality of sperms from males with moderate idiopathic oligozoospermia Medica 22 614–618
E Bedir IA Khan (2000) ArticleTitleNew steroidal glycosides from the fruits of Tribulus terrestris J. Nat. Prod. 63 1699–1701 Occurrence Handle10.1021/np000353b Occurrence Handle11141122 Occurrence Handle1:CAS:528:DC%2BD3cXnsFylur8%3D
E Bedir IA Khan LA Walker (2002) ArticleTitleBiologically active steroidal glycosides from Tribulus terrestris Pharmazie 57 491–493 Occurrence Handle12168535 Occurrence Handle1:CAS:528:DC%2BD38XlsFSktr0%3D
Bombardelli E, Morazzoni P, Riva A & Seghizzi R (2003a) PCT Int. Appl. WO 0394, 943 (Cl. A61K35/78), 20 Nov 2003, IT Appl. 2002/MI 990, 10 May 2002.
Bombardelli E, Morazzoni P, Riva A & Seghizzi R (2003b) PCT Int. Appl. WO 0394, 944 (Cl. A61K35/78), 20 Nov 2003, IT Appl. 2002/MI 994, 10 May 2002.
CA Bourke GR Stevens MJ Carrigan (1992) ArticleTitleLocomotor effects in sheep of alkaloids identified in Australian Tribulus terrestris Aust. Vet. J. 69 163–165 Occurrence Handle1445080 Occurrence Handle1:CAS:528:DyaK3sXitFKi
AG Brown MD Vukovich ER Martini ML Kohut WD Franke DA Jackson DS King (2002) ArticleTitleEndocrine and lipid responses to chronic androstenediol – herbal supplementation in 30 to 58 year old men J. Am. Coll. Nutr. 20 520–528
JM Brown WT De Kock (1959) ArticleTitleChemical and physiological investigation of geeldikkop in sheep in South Africa South African Ind. Chem. 13 189–191 Occurrence Handle1:CAS:528:DyaF3cXksFCltQ%3D%3D
LE Cai FY Jing JG Zhang FK Pei XJ Xu SY Lui DM Xu (1999) ArticleTitleStudies on the chemical components of Tribulus terrestris Yaoxue Xuebao 34 759–761 Occurrence Handle1:CAS:528:DyaK1MXotVCqsro%3D
L Cai Y Wu J Zhang F Pei Y Xu S Xie D Xu (2001) ArticleTitleSteroidal saponins from Tribulus terrestris Planta Med. 67 196–198 Occurrence Handle10.1055/s-2001-11650 Occurrence Handle11301880 Occurrence Handle1:CAS:528:DC%2BD3MXisVGisbc%3D
HC Chiang TH Tseng CJ Wang CF Chen WS Kan (1991) ArticleTitleExperimental antitumor agents from Solanium indicum L Anticancer Res. 11 1911–1917 Occurrence Handle1768063 Occurrence Handle1:CAS:528:DyaK38Xhs1GrtL8%3D
RN Chopra SL Nayar IC Chopra (1956) Glossary of Indian␣Medicinal Plants Council of Scientific & Industrial Research New Delhi pp. 246–247
S Chu W Qu X Pang B Sun X Huang (2003) ArticleTitleEffect of saponin from Tribulus terrestris on hyperlipidemia Zhong Yao Cai 26 341–344 Occurrence Handle14535016
J Conrad D Dinchev I Klaiber S Mika I Kostova W Kraus (2004) ArticleTitleA novel furostanol saponin from Tribulus terrestris of Bulgarian origin Fitoterapia 75 117–122 Occurrence Handle10.1016/j.fitote.2003.09.001 Occurrence Handle15030914 Occurrence Handle1:CAS:528:DC%2BD2cXitFKksb0%3D
BP Da Silva RR Bernardo JP Parente (1999) ArticleTitleA furostanol glycoside from rhizomes of Costus spicatus Phytochemistry 51 931–935 Occurrence Handle10423863 Occurrence Handle1:CAS:528:DyaK1MXkslSit7k%3D
E. De Combarieu N Fuzzati M Lovati E Mercalli (2003) ArticleTitleFurostanol saponins from Tribulus terrestris Fitoterapia 74 583–591 Occurrence Handle10.1016/S0367-326X(03)00152-7 Occurrence Handle12946722 Occurrence Handle1:CAS:528:DC%2BD3sXmslemtro%3D
M Deepak G Dipankar D Prashanth MK Asha A Amit BV Venkataraman (2002) ArticleTitleTribulosin and β-sitosterol-d-glucoside, the anthelmintic principles of Tribulus terrestris Phytomedicine 9 753–756 Occurrence Handle10.1078/094471102321621395 Occurrence Handle12587699 Occurrence Handle1:CAS:528:DC%2BD3sXisVKhu7k%3D
WT De Kock PR Enslin (1958) ArticleTitleChemical investigation of photosensitization diseases of domestic animals. I. Isolation and characterization of steroidal sapogenins from Tribulus terrestris J. S. African Chem. Inst. 11 33–36. Occurrence Handle1:CAS:528:DyaG1cXpvVKmsw%3D%3D
Dinchev D & Kostova I (Suppl., 2005) HPLC screening of Tribulus terrestris from different geographical regions for the presence of protodioscin, prototribestin and rutin. Pharmacia LII: 82.
ES Drewes J George F Khan (2003) ArticleTitleRecent findings on natural products with erectile-dysfunction activity Phytochemistry 62 1019–1025 Occurrence Handle10.1016/S0031-9422(02)00621-0 Occurrence Handle12591255 Occurrence Handle1:CAS:528:DC%2BD3sXht1Crsbw%3D
CR Eddy EW Monroe MK Scott (1953) ArticleTitleCatalog of infrared absorption spectra of steroidal sapogenin acetates Anal. Chem. 25 266–271 Occurrence Handle10.1021/ac60074a016 Occurrence Handle1:CAS:528:DyaG3sXjtFWntQ%3D%3D
S Fang C Hao W Sun Z Liu S Liu (1998) ArticleTitleRapid analysis of steroidal saponin mixture using electrospray ionization mass spectrometry combined with sequential tandem mass spectrometry Rapid Commun. Mass Spectrom. 12 589–594 Occurrence Handle10.1002/(SICI)1097-0231(19980529)12:10<589::AID-RCM200>3.0.CO;2-Q Occurrence Handle9621442 Occurrence Handle1:CAS:528:DyaK1cXjt12jt7w%3D
S Fang C Hao Z Liu F Song S Liu (1999) ArticleTitleApplication of electrospray ionization mass spectrometry combined with sequential tandem mass spectrometry techniques for the profiling of steroidal saponin mixture extracted from Tribulus terrestris Planta Med. 65 68–73 Occurrence Handle10.1055/s-1999-13966 Occurrence Handle1:CAS:528:DyaK1MXhsVSjtrk%3D
D Frohne (1999) ArticleTitleEin neues Dopingmittel? Dtsch. Apoth. Ztg. 139 4752–4754
M Ganzera E Bedir IA Khan (2001) ArticleTitleDetermination of steroidal saponins in Tribulus terrestris by reversed-phase high-performance liquid chromatography and evaporative light scattering detection J. Pharm. Sci. 90 1752–1758 Occurrence Handle10.1002/jps.1124 Occurrence Handle11745732 Occurrence Handle1:CAS:528:DC%2BD3MXosVKltrk%3D
K Gauthaman PG Adaikan RNV Prasad (2002) ArticleTitleAphrodisiac properties of Tribulus terrestris extract (protodioscin) in normal and castrated rats Life Sci. 71 1385–1396 Occurrence Handle10.1016/S0024-3205(02)01858-1 Occurrence Handle12127159 Occurrence Handle1:CAS:528:DC%2BD38Xlt12ku7s%3D
A Gheorghiu E Ionescu-Matiu (1968a) ArticleTitlePresence of chlorogenin next to diosgenin and gitogenin in Tribulus terrestris Ann. Pharm. Fr. 26 745–798 Occurrence Handle1:CAS:528:DyaF1MXktlKgtLs%3D
A Gheorgiu E Ionescu-Matiu (1968b) ArticleTitleSteroid saponins. Presence of chlorogenin in Tribulus terrestris Stud. Cerect. Biochem. 11 269–273
Gyulemetova R, Tomova M, Simova M, Pangarova T & Peeva S (1982) Determination of furostanol saponins in the preparation Tribestan®. Pharmazie 37, H.4: 296.
K Hu A Dong X Yao H Kobayashi S Iwasaki (1996) ArticleTitleAntineoplastic agents: I. Three spirostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca Planta Med. 62 573–575 Occurrence Handle9000889 Occurrence Handle1:CAS:528:DyaK2sXht1WgtA%3D%3D
K Hu X Yao (2002) ArticleTitleProtodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel Planta Med. 68 297–301 Occurrence Handle11988850 Occurrence Handle1:CAS:528:DC%2BD38XjvFSiu7Y%3D
K Hu X Yao (2003) ArticleTitleThe cytotoxicity of methyl protodioscin against human cancer cell lines in vitro Cancer Invest. 21 389–393 Occurrence Handle10.1081/CNV-120018230 Occurrence Handle12901285 Occurrence Handle1:CAS:528:DC%2BD3sXmvFSmsrY%3D
JW Huang SH Jiang CH Tan DY Zhu (2002) ArticleTitleStructural elucidation of three new steroid sapogenins Youji Huaxue 22 917–921 Occurrence Handle1:CAS:528:DC%2BD38XoslOkurs%3D
JW Huang CH Tan SH Jiang DY Zhu (2003a) ArticleTitleTerrestrinins A and B, two new steroid saponins from Tribulus terrestris J. Assian Nat. Prod. Res. 5 285–290 Occurrence Handle1:CAS:528:DC%2BD3sXns1GrsLg%3D
JW Huang SH Jiang CH Tan DY Zhu (2003b) ArticleTitleSapogenins from Tribulus terrestris Nat. Prod. Res. Develop. 15 101–103 Occurrence Handle1:CAS:528:DC%2BD3sXmsVaksb8%3D
GB Iskenderov (1970) ArticleTitleSteroidal sapogenins from Tribulus terrestris Khim. Prir. Soedin. 6 488–489 Occurrence Handle1:CAS:528:DyaE3MXhtVGn
T Kawasaki T Komori K Miyahara T Nohara I Hosokawa K Mihashi (1974) ArticleTitleFurostanol bisgglycosides coresponding to dioscin and gracillin Chem. Pharm. Bull. 22 2164–2175 Occurrence Handle1:CAS:528:DyaE2MXjtFCrsw%3D%3D
S Kianbakht F Jahaniani (2003) ArticleTitleEvaluation of Antibacterial Activity of Tribulus terrestris L. Growing in Iran Iranian J. Pharmacol. Therapeutics 2 22–24
PK Kintya ED Perepelitsa VY Chirva LG Kretsu (1972) ArticleTitleSteroid saponins. II. Glycosides of Tribulus terrestris Khim. Prir. Soedin. 8 475–477 Occurrence Handle1:CAS:528:DyaE3sXhvFyr
I Kostova D Dinchev GH Rentsch V Dimitrov A Ivanova (2002) ArticleTitleTwo new sulfated furostanol saponins fromTribulus terrestris Z. Naturforsch. 57c 33–38
JX Li Q Shi QB Xiong JK Prasain Y Tezuka T Hareyama ZT Wang K Tanaka T Namba S Kadota (1998) ArticleTitleTribulasamides A and B, new hepatoprotective lignanamides from fruits of Tribulus terrestris: indication of cytoprotective activity in Murine hepatocyte culture Planta Med. 64 628–631 Occurrence Handle9810268 Occurrence Handle1:CAS:528:DyaK1cXmvFOht7c%3D
M Li W Qu Y Wang H Wan C Tian (2002) ArticleTitleHypoglycemic effect of saponin from Tribulus terrestris Zhong Yao Cai. 25 420–422 Occurrence Handle12583337
ZX Lin JR Hoult A Raman (1999) ArticleTitleSulphorhodamine B assay for measuring proliferation of a pigmented melanocyte cell line and its application to the evaluation of crude drugs used in the treatment of vitiligo J. Ethnopharmacol. 66 141–150 Occurrence Handle10.1016/S0378-8741(98)00199-8 Occurrence Handle10433470 Occurrence Handle1:STN:280:DyaK1MzmtVymsA%3D%3D
SY Liu M Cui ZQ Liu F Song WJ Mo (2004) ArticleTitleStructural analysis of saponins from medicinal herbs using electrospray ionisation tandem mass spectrometry J. Am. Soc. Mass. Spectrom. 15 133–141 Occurrence Handle10.1016/j.jasms.2003.09.013 Occurrence Handle14766280 Occurrence Handle1:CAS:528:DC%2BD2cXptVChtw%3D%3D
SB Mahato NP Sahu AN Ganguiy K Miyahara T Kawasaki (1981) ArticleTitleSteroidal glycosides of Tribulus terrestris Linn J. Chem. Soc. Perkin I 9 2405–2410
SB Mahato AN Ganguly NP Sahu (1982) ArticleTitleSteroid saponins Phytochemistry 21 959–978 Occurrence Handle10.1016/S0031-9422(00)82400-0 Occurrence Handle1:CAS:528:DyaL38XkvVOisrk%3D
MS Mangle CI Jolly (1998) ArticleTitleHPTLC studies on Tribulus terrestris L. (Chota Gokru) and Pedalium murex L. (Bada Gokhru) Indian Drugs 35 189–194 Occurrence Handle1:CAS:528:DyaK1cXjtF2hsL0%3D
HE Matschenko R Gulemetova PK Kintya AS Shashkov (1990) ArticleTitleA sulfated glycoside from the preparation “Tribestan” Khim. Prir. Soedin 5 649–652
Milanov S, Maleeva E & Tashkov M (1981) Tribestan effect on the concentration of some hormones in the serum of healthy subjects. (Pharmachim, Bulgaria - Company documentation).
CO Miles AL Willkins SC Munday A Flaønen PT Holland BL Smith (1993) ArticleTitleIdentification of insoluble salts of the β-d-glucuronides of episarsasapogenin and epismilagenin in the bile of lambs with alved and examination of Nartecium ossifragum, Tribulus terrestris, and Panicum miliaceum for sapogenins J. Agric. Food Chem. 41 914–917 Occurrence Handle10.1021/jf00030a015 Occurrence Handle1:CAS:528:DyaK3sXltFCksr8%3D
Y Mimaki Y Takaashi M Kuroda Y Sashida (1997) ArticleTitleSteroidal glucosides from leaves of Cordyline stricta Phytochemistry 45 1229–1234 Occurrence Handle10.1016/S0031-9422(97)00109-X Occurrence Handle1:CAS:528:DyaK2sXkt1ejtr8%3D
SM Morrison JK Scott (1996a) ArticleTitleVariations in populations of Tribulus terrestris (Zygophyllaceae). 2. Chromosome numbers Aust. J. Bot. 44 191–199
SM Morrison JK Scott (1996b) ArticleTitleVariations in populations of Tribulus terrestris (Zygophyllaceae) 3 Isozyme analysis Aust. J. Bot. 44 201–212
N Mulinacci P Vignolini G Marca Particlela G Pieraccani M Innocenti FF Vincieri (2003) ArticleTitleFood supplements of Tribulus terrestris L.: an HPLC-ESI-MS method for an estimation of the saponin content Chromatographia 57 581–592 Occurrence Handle1:CAS:528:DC%2BD3sXksVOju7w%3D
D Obreshkova T Pangarova S Mitkov D Dinchev (1998) ArticleTitleComparative analytical investigation of Tribulus terrestris preparation Farmatsiya (Sofia) 45 10–12 Occurrence Handle1:CAS:528:DC%2BD3cXitVKku7w%3D
ED Perepelitsa PK Kintya (1975) ArticleTitleChemical investigation of steroid glycosides from Tribulus terrestris. IV. Steroid saponins Khim. Prir. Soedin. 2 260–261
Protich M, Tsvetkov D, Nalbanski B, Stanislavov R &␣Katsarova M (1981) Clinical trial of Tribestan on infertilemales. (Pharmachim, Bulgaria - Scientific-technical report).
MC Recio JL Rios A Villar (1989) ArticleTitleAntimicrobial activity of selected plants employed in the spanish mediterranean area. Part II Phytother. Res. 3 77–80
YJ Ren HS Chen GJ Yang H Zhu (1994) ArticleTitleIsolation and identification of a new derivative of cinnamic amide from Tribulus terrestris Acta Pharm. Sin. 29 204–206 Occurrence Handle1:CAS:528:DyaK2cXlsFehurc%3D
ES Rothman ME Wall CR Eddy (1952) ArticleTitleSteroidal sapogenins III. Structure of steroidal saponins J. Am. Chem. Soc. 74 4013–4016 Occurrence Handle1:CAS:528:DyaG3sXktFehtQ%3D%3D
NAM Saleh AA Ahmed MF Abdalla (1982) ArticleTitleFlavonoid Glycosides of Tribulus pentandrus and Tribulus terrestris Phytochemistry 21 1995–2000 Occurrence Handle10.1016/0031-9422(82)83030-6 Occurrence Handle1:CAS:528:DyaL3sXmvVyjsw%3D%3D
S Sang A Lao H Wang Z Chen (1999) ArticleTitleTwo new spirostanol saponins from Allium tuberosum J. Nat. Prod 62 1028–1029 Occurrence Handle10.1021/np980486l Occurrence Handle10425134 Occurrence Handle1:CAS:528:DyaK1MXjslWmsbk%3D
JK Scott SM Morrison (1996) ArticleTitleVariarion in populations of Tribulus terrestris (Zygophyllaceae) I Burr morphology Aust. J. Bot. 44 175–190
Y Shao O Poobrasert EJ Kennelly CK Chin CT Ho MT Huang SA Garrison GA Cordell (1997) ArticleTitleSteroidal saponins from Asparagus officinalis and their cytotoxic activity Planta Med. 63 258–262 Occurrence Handle9225609 Occurrence Handle1:CAS:528:DyaK2sXjvF2rsrk%3D
HC Sharma JL Narula (1977) ArticleTitleChemical investigation of flowers of Tribulus terrestris Chem. Era 13 15–17 Occurrence Handle1:CAS:528:DyaE1cXhvFSmtw%3D%3D
N Stoyanov (1973) Our Medicinal Plants NumberInSeries2 Nauka & Izkustvo Sofia 454–455
B Sun W Qu Z Bai (2003) ArticleTitleThe inhibitory effect of saponins from Tribulus terrestris on Bcap-37 breast cancer line in␣vitro Zhong Yao Cai 26 104–106 Occurrence Handle12795220
WJ Sun J Gao GZ Tu ZW Guo YM Zhang (2002) ArticleTitleA new steroidal saponin from Tribulus terrestris Linn Nat. Prod. Lett. 16 243–247 Occurrence Handle12168759 Occurrence Handle1:CAS:528:DC%2BD38XlvFegtbg%3D
M Tomova (1980) ArticleTitleThe furostanol saponins Farmatsya (Sofia) 30 16–20 Occurrence Handle1:CAS:528:DyaL3cXmt1Gmt7g%3D
M Tomova D Panova (1965) ArticleTitleSteroid sapogenins. Isolation of diosgenin from Tribulus terrestris L Farmatsiya (Sofia) 15 211–214
Tomova M, Panova D, Zarkova S & Dikova V (1966) Bulg. Patent (11) 11450, 30 1/02 A61K/1966.
M Tomova D Panova NS Wulfson (1974) ArticleTitleSteroid saponins and sapogenins IV. Saponins from Tribulus terrestris Planta Med. 25 231–237 Occurrence Handle1:CAS:528:DyaE2cXkt1ejur0%3D
MP Tomova DM Bocheva WG Zaikin NS Wulfson (1977) ArticleTitleSteroid saponins and sapogenins V. Hecogenin from Tribulus terrestris L Planta Med. 32 223–224 Occurrence Handle1:CAS:528:DyaE1cXmtVSlsw%3D%3D
MP Tomova R Gyulemetova (1978a) ArticleTitleSteroidsaponins and steroidsapogenins. VI. Furostanol bisglycoside from Tribulus terrestris L Planta Med. 34 188–191 Occurrence Handle1:CAS:528:DyaE1MXhtlGjtLY%3D
Tomova M & Gyulemetova R (1978b) Bulg. Patent (11) 26221, 2(51) A 1K 35/1978.
Tomova M, Gyulemetova R & Zarkova S (1978) An agent for stimulation of sexual function. Bulg. Patent (11) 27584 A61K35/1978.
Tomova M, Gyulemetova R, Zarkova S, Peeva S, Pangarova T & Simova M (1981) Steroidal saponins from Tribulus terrestris L. with a stimulating action on the sexual functions. First Intern. Conf. Chem. Biotechnol. Biol. Active Nat. Prod., Proceedings, Varna, September 3: 289–291.
F Tosun M Tanker M Coskun A Tosun (1991) ArticleTitleDetermination of diosgenin in Tribulus terrestris L. growing in Turkey by HPLC Pharmacia (Ankara) 31 90–96. Occurrence Handle1:CAS:528:DyaK38XitlWrtbk%3D
TG Tutin (1968) Rosaceae to Umbelliferae TG Tutin VH Heywood NA Burges DM Moore DH Valentine SM Walters DA Webb (Eds) Flora Europaea Cambridge at the University press Cambridge 205
Viktorov I, Kaloyanov D, Lilov AI, Zlatanova L & Kasabov V (1982) Clinical investigation on Tribestan in males with disorders in the sexual function. Med. Biol. Inform. (Pharmachim, Bulgaria – Company documentation).
ME Wall CR Eddy ML McClennan ME Klumpp (1952) ArticleTitleDetection and estimation of steroidal sapogenins in plant tissue Anal. Chem. 24 1337–1341 Occurrence Handle10.1021/ac60068a018 Occurrence Handle1:CAS:528:DyaG38XmslGisg%3D%3D
B Wang L Ma T Lui (1990) ArticleTitle406 cases of angina pectoris in coronary heart disease treated with saponin of Tribulus terrestris Zhong Xi Yi Jie He Za Zhi 10 85–87 Occurrence Handle2364467 Occurrence Handle1:STN:280:By%2BA3cvpvFY%3D
Y Wang K Othani R Kasai K Yamasaki (1996) ArticleTitleSteroidal saponins from fruits of Tribulus terrestris Phytochemistry 42 1417–1422
Y Wang K Ohtani R Kasai K Yamasaki (1997) ArticleTitleSteroidal saponins from fruits of Tribulus terrestris Phytochemistry 45 811–817 Occurrence Handle1:CAS:528:DyaK2sXktVektbY%3D
AL Wilkins CO Miles WT De Kock GL Erasmus AT Basson TS Kellerman (1996) ArticleTitlePhotosensitivity in South Africa. IX. Structure elucidation of a beta-glucosidase-treated saponin from Tribulus terrestris, and the identification of saponin chemotypes of South African T. terrestris Onderstepoort J.␣Vet. Res. 63 327–334 Occurrence Handle9173364 Occurrence Handle1:STN:280:ByiB3sjlsl0%3D
G Wu S Jiang F Jiang D Zhu H Wu S Jiang (1996) ArticleTitleSteroidal glycosides from Tribulus terrestris Phytochemistry 42 1677–1681 Occurrence Handle8783840 Occurrence Handle1:CAS:528:DyaK28XkvVKktbs%3D
TS Wu LS Shi SC Kuo (1999) ArticleTitleAlkaloids and other constituents from Tribulus terrestris Phytochemistry 50 1411–1415 Occurrence Handle1:CAS:528:DyaK1MXjtFChurk%3D
Y Xu S Xie H Zhao D Han T Xu D Xu (2001) ArticleTitleStudies of the chemical constituents from Tribulus terrestris Yaoxue Xuebao 36 750–753 Occurrence Handle1:CAS:528:DC%2BD3MXovFCjsr8%3D
YX Xu HS Chen WY Liu ZB Gu HQ Liang (1998) ArticleTitleTwo sapogenins from Tribulus terrestris Phytochemistry 49 199–201 Occurrence Handle1:CAS:528:DyaK1cXmt1aqu74%3D
YX Xu HS Chen HQ Liang ZB Gu WY Liu WN Leung TJ Li (2000) ArticleTitleThree new saponins from Tribulus terrestris Planta Med. 66 545–550 Occurrence Handle10.1055/s-2000-8609 Occurrence Handle10985082 Occurrence Handle1:CAS:528:DC%2BD3cXlvFaisLo%3D
R Zafar M Lawani AA Siddiqui (1989) ArticleTitleHecogenin and neohecogenin from the root of Tribulus terrestris Indian Drugs 26 460.
R Zafar V Aeri (1992) ArticleTitleConstituents of Tribulus terrestris flowers Fitoterapia 63 90 Occurrence Handle1:CAS:528:DyaK38XkvVKrsr8%3D
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In this review the steroidal saponins found in T. terrestris are presented, covering the literature up to 2004. The data reveal clear difference in the saponin composition of samples from this plant species collected from different geographical regions. A comprehensive account on the biological activity of extracts and individual saponins is also included.
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Kostova, I., Dinchev, D. Saponins in Tribulus terrestris – Chemistry and Bioactivity. Phytochem Rev 4, 111–137 (2005). https://doi.org/10.1007/s11101-005-2833-x
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DOI: https://doi.org/10.1007/s11101-005-2833-x