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Medication exposure of the dyad patient-caregiver in Alzheimer’s disease and related dementias: a cross-sectional study

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Abstract

Background

Patients with Alzheimer’s disease and related dementias and their caregivers can be defined as people with higher risk of developing medication-related problems due to aging and polypharmacy.

Aim

To assess the medication exposure of patient with Alzheimer’s disease and related dementias and their caregivers.

Method

Ancillary cross-sectional study based on baseline medication data of the PHARMAID RCT. The PHARMAID study was a multi-center RCT assessing an integrated pharmaceutical care at a psychosocial program. Older outpatients with Alzheimer’s disease and related dementias and their older caregivers were eligible for inclusion. Baseline medication data were used to assess the medication exposure, illustrated by the number of medications, the prevalence of potentially inappropriate medications (PIMs) using the EU(7)-PIM list and the Medication Regimen Complexity Index (MRCI).

Results

Seventy-three dyads were included in this ancillary study. The mean numbers (SD) of medications used by patients was 6.8 (2.6) and by caregivers was 4.7 (3.7). Overall, 60.3% of patients used at least one PIM and 47.9% of caregivers. Regarding the medication regimen complexity, the mean MRCI was 16.3(8.1) for patients and 11.3(10.5) for caregivers.

Conclusion

The results of this study confirm the relevance of carrying out medication review with patients, but also with their caregivers who can be considered as hidden patients.

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Acknowledgements

We thank all healthcare professionals and investigators involved in the PHARMAID study for the study implementation and the inclusions.

Funding

This work was supported by the French Ministry of Health, Grant Number 14-0568 (PREPS2014).

Author information

Authors and Affiliations

  1. Pharmaceutical Unit, Department of Pharmacy, Charpennes Hospital, Hospices Civils de Lyon, University Hospital of Lyon, 69100, Villeurbanne, France

    Teddy Novais & Christelle Mouchoux

  2. Lyon Institute for Aging, Hospices Civils de Lyon, 69000, Lyon, France

    Teddy Novais, Denis Federico, Pierre Krolak-Salmon & Christelle Mouchoux

  3. Research on Healthcare Performance (RESHAPE), INSERM U1290, University Lyon1, 69000, Lyon, France

    Teddy Novais

  4. REIPO Team, La Grave Hospital, Toulouse University Hospital, 31000, Toulouse, France

    Soraya Qassemi

  5. Department of Pharmacy, Toulouse University Hospital, 31000, Toulouse, France

    Philippe Cestac & Cécile McCambridge

  6. Centre for Epidemiology and Population Health Research (CERPOP), UMR 1027, INSERM, University of Toulouse, 31000, Toulouse, France

    Philippe Cestac & Hélène Villars

  7. Geriatric Department, Toulouse University Hospital, 31000, Toulouse, France

    Hélène Villars

  8. ULR 7365-GRITA-Groupe de Recherche sur les Formes Injectables et les Technologies Associées, University Lille, 59000, Lille, France

    Bertrand Decaudin

  9. Pharmacie Institute, CHU Lille, 59000, Lille, France

    Bertrand Decaudin & Mathilde Dambrine

  10. Geriatric Department, CHU Lille, 59000, Lille, France

    Dominique Huvent-Grelle

  11. Department of Geriatric Psychiatry, CHU Lille, 59000, Lille, France

    Jean Roche

  12. Clinical and Research Memory Centre of Lyon (CMRR), Charpennes Hospital, University Hospital of Lyon, 69100, Villeurbanne, France

    Denis Federico

  13. Clinical Research Centre (CRC) - VCF (Aging – Brain - Frailty), Charpennes Hospital, University Hospital of Lyon, 69000, Villeurbanne, Lyon, France

    Pierre Krolak-Salmon & Christelle Mouchoux

  14. Neuroscience Research Centre of Lyon (CRNL), 69000, Lyon, France

    Pierre Krolak-Salmon & Christelle Mouchoux

Authors
  1. Teddy Novais
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  2. Soraya Qassemi
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  3. Philippe Cestac
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  4. Cécile McCambridge
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  5. Hélène Villars
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  6. Bertrand Decaudin
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  7. Mathilde Dambrine
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  8. Dominique Huvent-Grelle
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  9. Jean Roche
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  10. Denis Federico
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  11. Pierre Krolak-Salmon
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  12. Christelle Mouchoux
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Corresponding author

Correspondence to Teddy Novais.

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Cite this article

Novais, T., Qassemi, S., Cestac, P. et al. Medication exposure of the dyad patient-caregiver in Alzheimer’s disease and related dementias: a cross-sectional study. Int J Clin Pharm 46, 205–209 (2024). https://doi.org/10.1007/s11096-023-01623-8

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  • DOI: https://doi.org/10.1007/s11096-023-01623-8

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