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Publisher Correction to: International Journal of Clinical Pharmacy (2022) 44:843–851 https://doi.org/10.1007/s11096-022-01415-6
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Abstract
Background Despite available meta-analyses, comparative efficacy and safety between bevacizumab and cetuximab-containing therapies in treating advanced colorectal cancer (CRC) still need to be elucidated.
Aim This meta-analysis aimed to investigate the efficacy and grade 3–5 treatment-related adverse events (TARE3-5) of bevacizumab versus cetuximab in treating advanced CRC.
Method Randomized controlled trials (RCTs) and observational cohort studies were searched from electronic databases. Data on overall response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and TARE (3–5) were synthesized.
Results Five RCTs and four observational cohort studies (2970 patients) were included. The bevacizumab-containing group was associated with a significantly lower ORR (risk ratio RR 0.91, 95% confidence interval CI 0.85–0.97, P = 0.006) than the cetuximab group. Bevacizumab was associated with significant superior DCR (RR 1.05, 95% CI 1.01 to 1.10, P = 0.02) and prolonged OS (hazard ratio HR 0.81, 95% CI 0.74–0.90, P < 0.0001) than cetuximab. No significant differences were observed for PFS (HR 0.97, 95% CI 0.92–1.03, P = 0.33) between the groups. Bevacizumab showed a lower rate of skin disorders (RR 0.10, 95% CI 0.02–0.43, P = 0.002) than cetuximab. There were no significant differences between the groups in the overall rate of TRAE3-5 (RR 0.92, 95% CI 0.84–1.01, P = 0.08). Subgroup analysis found a lower TARE3-5 rate in the bevacizumab group in RCTs (RR 0.91, 95% CI 0.83–1.00, P = 0.04).
Conclusion Bevacizumab could increase DCR, prolong OS, and lower the skin disorder rate to treat patients with advanced CRC.
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Cui, Y., Guo, Y. Publisher Correction to: The effectiveness and safety of bevacizumab versus cetuximab in the treatment of colorectal cancer: a systematic review and meta-analysis. Int J Clin Pharm 44, 1572 (2022). https://doi.org/10.1007/s11096-022-01479-4
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DOI: https://doi.org/10.1007/s11096-022-01479-4