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Bacillus coagulans TBC169 probiotics for the recovery of intestinal function after gynecological laparoscopic surgery: a randomized, placebo-controlled trial

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A Publisher Correction to this article was published on 02 November 2022

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Abstract

Background

Evidence suggests that Bacillus coagulans TBC169 can improve intestinal motility.

Aim

To investigate the effectiveness and safety of Bacillus coagulans TBC169 probiotics in promoting the recovery of intestinal function after gynecological laparoscopic surgery.

Method

Patients who underwent laparoscopic surgeries due to gynecological diseases were randomly assigned to the high-dose, conventional-dose, and the placebo-control groups (1:1:1 ratio). The primary outcome was the time to the first passage of flatus time (FFT). Secondary outcomes were the time to the first defecation (FDT), the time to the first bowel sounds (TFBS), the duration of hospital stay (DHS), and the incidence of postoperative adverse events (AEs).

Results

Compared to the placebo-control group, shorter FFT values were observed in the conventional-dose (23.15 h vs. 29.10 h, P < 0.05) and high-dose (19.15 h vs. 29.10 h, P < 0.001) groups. Similar trends were observed regarding TFBS in the conventional-dose (18.50 h vs. 21.10 h, P < 0.05) and high-dose (15.20 h vs. 21.10 h, P < 0.001) groups. There were no significant differences in FFT and TFBS between the intervention groups. Compared to the placebo-control group, lower incidences of postoperative adverse events were observed in the conventional-dose (12.50% vs. 40.00%, P < 0.05) and the high-dose (5.00% vs. 40.00%, P < 0.001) groups. However, there were no significant differences between these intervention groups.

Conclusion

Bacillus coagulans TBC169 probiotics can accelerate intestinal function recovery, and reduce postoperative adverse events in patients after gynecological laparoscopic surgery.

The study protocol was registered at the Chinese Clinical Trial Registry (ChiCTR2200059518).

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Acknowledgements

Authors are grateful to all participants and gynecologists who participated in this study.

Funding

None.

Author information

Author notes

  1. Zhihong Li and Zhaobo Guan have contributed equally to this work.

Authors and Affiliations

  1. School of Pharmacy, Shanxi Medical University, Taiyuan, China

    Zhaobo Guan, Niuniu Bai, Ya Yan & Weihong Chen

  2. Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China

    Zhihong Li, Zhanqin Niu & Juan Xu

  3. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Zhihong Li, Zhanqin Niu & Juan Xu

  4. Department of Pharmacy, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, 99 Longcheng Street, Taiyuan, 030032, China

    Zhaobo Guan, Niuniu Bai, Ya Yan, Weiqi Gao & Weihong Chen

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  1. Zhihong Li
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The original online version of this article was revised: Font of “Impact statements” and heading sizes for ‘Aim’ and ‘Ethics approval’ are incorrect. ‘Conflict of interest’ should be ‘Conflicts of interest’. In Table 1, ‘Type of surgery, n (5)’ should be ‘Type of surgery, n (%)’. Reference 25 should have three authors “Hong HA, Duc le H, Cutting SM”. These errors have been corrected.

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Li, Z., Guan, Z., Bai, N. et al. Bacillus coagulans TBC169 probiotics for the recovery of intestinal function after gynecological laparoscopic surgery: a randomized, placebo-controlled trial. Int J Clin Pharm 44, 1287–1295 (2022). https://doi.org/10.1007/s11096-022-01451-2

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