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Association between reported medication adherence and health-related quality of life in adult patients with haemophilia


Background Medication adherence is an important issue, not just health-related, for patients with haemophilia. Poor medication adherence to long-term therapies limits the potential of effective treatments to improve patients’ health-related quality of life. Objective The aim of this study was to investigate the association of reported medication adherence and health-related quality of life in patients with haemophilia. Setting Data were collected from patients at University Hospital Centre Zagreb, Croatia and at University Medical Centre Ljubljana, Slovenia. Method Adult male patients with severe or moderate haemophilia receiving prophylactic treatment were eligible for the study. Main outcome measure Implementation phase of medication adherence was assessed with the self-reported VERITAS-Pro instrument and health-related quality of life with SF-36v2. Results A total of 82 participants were included in the study (median age was 44.50, range 18–73 years). The majority of our participants reported being adherent to medication (83%). Participants showed better health in the mental health domains and Mental Component Summary than in the physical health domains and Physical Component Summary. After controlling for demographic, socioeconomic and clinical predictors, better reported medication adherence explained an additional 4–6% of better health variance in Bodily Pain and Social Functioning domains and Mental Component Summary. Conclusion We found that reported medication adherence can contribute to better health-related quality of life in patients with haemophilia. Since life with a chronic condition is demanding, it is an important finding that medication adherence to replacement therapy can improve life conditions for patients with haemophilia.

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The authors would like to thank all the participants who took part in the study. The authors would like to thank the Indiana Hemophilia & Thrombosis Center, Inc. for providing VERITAS-Pro and OptumInsight Life Sciences, Inc. for providing SF-36v2 for use in this study. The authors would also like to thank Bianca Dobson for language editing of this publication.


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Correspondence to Martina Bago.

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Bago, M., Butkovic, A., Preloznik Zupan, I. et al. Association between reported medication adherence and health-related quality of life in adult patients with haemophilia. Int J Clin Pharm 43, 1500–1507 (2021).

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  • Haemophilia A
  • Haemophilia B
  • Medication adherence
  • Quality of life