Abstract
Objective Evaluate the clinical, economic, and organizational impact of pharmaceutical interventions performed during medication review in a cognitive-behavioral unit. Setting Study conducted in a cognitive-behavioral unit with retrospective data from January 2011 to june 2017. Methods This study was conducted from retrospective data of medication review in a cognitive-behavioral unit. During medication review, pharmacists identified relevant drug related problems lead to a pharmaceutical intervention which is submitted to the physician. All pharmaceutical interventions carried out from January 2011 to june 2017 were retrospectively analyzed to evaluate their clinical, economic and organizational impact using a multidimensional tool. Main outcome measure CLinical, Economic and Organizational impact using the CLEO tool. Results During the study period, 543 drug related problems and pharmaceutical interventions were recorded for patients hospitalized in the cognitive-behavioral unit (79.0 ± 9.5 years, 59% female). The most common types of drug related problems identified were ‘non conformity to guidelines / contra-indication’ (28.7%), ‘drug without indication’ (21.7%), and ‘improper administration’ (15.1%). The majority of pharmaceutical interventions were considered to have at least a clinical significant impact from the pharmacist’s perspective (74%). Regarding the economic and organizational dimensions, 55.2% of pharmaceutical interventions would decrease the costs of care and 35.9% of pharmaceutical interventions would be favorable on the quality of care process. Conclusions The present study shows that the pharmacist may detect a high number of drug related problems with significant clinical relevance during medication review in a cognitive-behavioral unit. Describing and identifying significant pharmaceutical interventions in cognitive-behavioral unit patients allow us to better understand and improve clinical practice in this population.
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References
Strubel D. The specificities of care in cognitive-behavior units. Soins Gerontol. 2015;20(113):37–42.
Chan KY, Wang W, Wu JJ, Liu L, Theodoratou E, Car J, et al. Epidemiology of Alzheimer’s disease and other forms of dementia in China, 1990–2010: a systematic review and analysis. The Lancet. 2013;381(9882):2016–23.
Gurwitz JH, Field TS, Harrold LR, Rothschild J, Debellis K, Seger AC, et al. Incidence and preventability of adverse drug events among older persons in the ambulatory setting. JAMA. 2003;289(9):1107–16.
Campbell NL, Boustani MA, Skopelja EN, Gao S, Unverzagt FW, Murray MD. Medication adherence in older adults with cognitive impairment: a systematic evidence-based review. Am J Geriatr Pharmacother. 2012;10(3):165–77.
Pasqualetti G, Tognini S, Calsolaro V, Polini A, Monzani F. Potential drug-drug interactions in Alzheimer patients with behavioral symptoms. Clin Interv Aging. 2015;10:1457–66.
Johnell K. Inappropriate drug use in people with cognitive impairment and dementia: a systematic review. Curr Clin Pharmacol. 2015;10(3):178–84.
Sönnerstam E, Sjölander M, Lövheim H, Gustafsson M. Clinically relevant drug-drug interactions among elderly people with dementia. Eur J Clin Pharmacol. 2018;74(10):1351–60.
Bonfiglio V, Umegaki H, Kuzuya M. Potentially inappropriate medications and polypharmacy: a study of older people with mild cognitive impairment and mild dementia. J Alzheimers Dis (JAD). 2019;71(3):889–97.
Griese-Mammen N, Hersberger KE, Messerli M, Leikola S, Horvat N, van Mil JWF, et al. PCNE definition of medication review: reaching agreement. Int J Clin Pharm. 2018;40(5):1199–208.
van Mil JWF, Westerlund LOT, Hersberger KE, Schaefer MA. Drug-related problem classification systems. Ann Pharmacother. 2004;38(5):859–67.
Dooley MJ, Allen KM, Doecke CJ, Galbraith KJ, Taylor GR, Bright J, et al. A prospective multicentre study of pharmacist initiated changes to drug therapy and patient management in acute care government funded hospitals. Br J Clin Pharmacol. 2004;57(4):513–21.
Gillespie U, Alassaad A, Henrohn D, Garmo H, Hammarlund-Udenaes M, Toss H, et al. A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial. Arch Intern Med. 2009;169(9):894–900.
Mulvogue K, Roberts JA, Coombes I, Cottrell N, Kanagarajah S, Smith A. The effect of pharmacists on ward rounds measured by the STOPP/START tool in a specialized geriatric unit. J Clin Pharm Ther. 2017;42(2):178–84.
El Morabet N, Uitvlugt EB, van den Bemt BJF, van den Bemt PMLA, Janssen MJA, Karapinar-Çarkit F. Prevalence and preventability of drug-related hospital readmissions: a systematic review. J Am Geriatr Soc. 2018;66(3):602–8.
Vo T-H, Charpiat B, Catoire C, Juste M, Roubille R, Rose F-X, et al. Tools for Assessing Potential Significance of Pharmacist Interventions: A Systematic Review. Drug Saf. 2016;39(2):131–46.
Allenet B, Bedouch P, Rose F-X, Escofier L, Roubille R, Charpiat B, et al. Validation of an instrument for the documentation of clinical pharmacists’ interventions. Pharm World Sci PWS. 2006;28(4):181–8.
Bedouch P, Sylvoz N, Charpiat B, Juste M, Roubille R, Rose F-X, et al. Trends in pharmacists’ medication order review in French hospitals from 2006 to 2009: analysis of pharmacists’ interventions from the Act-IP© website observatory. J Clin Pharm Ther. 2015;40(1):32–40.
Vo T. Evaluation of the potential impact of pharmacist interventions: development and validation of the CLEO multidimensional tool. [Internet]. Université Grenoble Alpes, France; 2015. https://tel.archives-ouvertes.fr/tel-01315619/document
Stämpfli D, Baumgartner P, Boeni F, Bedouch P, Lampert ML, Hersberger KE. Translation and validation of a tool to assess the impact of clinical pharmacists’ interventions. Int J Clin Pharm. 2019;41(1):56–64.
Mouchoux C, Viprey M, Loue C, Ottomani H, Bezel C, Divoux E, et al. Intégration du pharmacien-clinicien dans l’optimisation thérapeutique des patients avec troubles neurocognitifs pris en charge en unité cognitivocomportementale. Cah Année Gérontologique. 2014;6(2):37–43.
Ziane A, Ngami C, Youb R, Atri MH, Aikpa R, Kabirian F, et al. Evaluating the quality of pharmacists’ interventions in older patient than 75 years. J Pharm Clin. 2013;32(4):243–9.
Cortejoso L, Dietz RA, Hofmann G, Gosch M, Sattler A. Impact of pharmacist interventions in older patients: a prospective study in a tertiary hospital in Germany. Clin Interv Aging. 2016;11:1343–50.
Nguyen TA, Gilmartin-Thomas J, Tan ECK, Kalisch-Ellett L, Eshetie T, Gillam M, et al. The impact of pharmacist interventions on quality use of medicines, quality of life, and health outcomes in people with dementia and/or cognitive impairment: a systematic review. J Alzheimers Dis. 2019;71(1):83–96.
Novais T, Mouchoux C. Pharmaceutical care for patients and their caregivers in Alzheimer’s disease and related disorders: a review and new perspectives. Geriatr Psychol Neuropsychiatr Vieil. 2019;17(1):7–19.
Sjölander M, Lindholm L, Pfister B, Jonsson J, Schneede J, Lövheim H, et al. Impact of clinical pharmacist engagement in ward teams on the number of drug-related readmissions among older patients with dementia or cognitive impairment: an economic evaluation. Res Soc Adm Pharm. 2019;15(3):287–91.
Hatoum HT, Hutchinson RA, Witte KW, Newby GP. Evaluation of the contribution of clinical pharmacists: inpatient care and cost reduction. Drug Intell Clin Pharm. 1988;22(3):252–9.
Nesbit TW, Shermock KM, Bobek MB, Capozzi DL, Flores PA, Leonard MC, et al. Implementation and pharmacoeconomic analysis of a clinical staff pharmacist practice model. Am J Health Syst Pharm. 2001;58(9):784–90.
Bosma L, Jansman FGA, Franken AM, Harting JW, Van den Bemt PMLA. Evaluation of pharmacist clinical interventions in a Dutch hospital setting. Pharm World Sci PWS. 2008;30(1):31–8.
Yailian A-L, Revel E, Tardy C, Fontana A, Estublier C, Decullier E, et al. Assessment of the clinical relevance of pharmacists’ interventions performed during medication review in a rheumatology ward. Eur J Intern Med. 2019;59:91–6.
Pérez-Moreno MA, Rodríguez-Camacho JM, Calderón-Hernanz B, Comas-Díaz B, Tarradas-Torras J. Clinical relevance of pharmacist intervention in an emergency department. Emerg Med J EMJ. 2017;34(8):495–501.
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The authors thank the medical team of the cognitive-behavioral unit (Charpennes Hospital, Lyon Institute For Elderly, University Hospital of Lyon).
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Novais, T., Maldonado, F., Grail, M. et al. Clinical, economic, and organizational impact of pharmacists’ interventions in a cognitive-behavioral unit in France. Int J Clin Pharm 43, 613–620 (2021). https://doi.org/10.1007/s11096-020-01172-4
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DOI: https://doi.org/10.1007/s11096-020-01172-4