International Journal of Clinical Pharmacy

, Volume 38, Issue 6, pp 1464–1476 | Cite as

Impact of adherence to antiemetic guidelines on the incidence of chemotherapy-induced nausea and vomiting and quality of life

  • Nibal AbunahlahEmail author
  • Mesut Sancar
  • Faysal Dane
  • Mustafa Kerem Özyavuz
Research Article


Background International guidelines are tools enabling physicians to incorporate the latest evidence based clinical information into practice. Objective This study aimed to evaluate the impact of antiemetic guidelines adherence on the incidence of chemotherapy-induced nausea and vomiting (CINV) and patient quality of life. Setting Marmara University Pendik Training and Research Hospital chemotherapy unit, Istanbul, Turkey. Method The study included 100 chemotherapy naive patients. Antiemetic prescribing patterns and their consistency with MASCC/ESMO 2014 guidelines were assessed. Patients recorded incidences of vomiting in a daily dairy and described their nausea using a 7-item Likert Scale. The incidence of CINV was recorded over five days. To assess the patient's quality of life, a modified Turkish version of the Functional Living Index-Emesis (FLIE) questionnaire was administered before and after receiving chemotherapy. A questionnaire on the existence and severity of side effects was developed and administered. Main outcome measures Incidence of side effects on CINV and quality of life according to the FLIE. Results The primary outcome revealed differences in complete control (no emetic episodes, rescue therapy or nausea), FLIE scores and side effects. Guidelines consistency was observed more with acute (A) than with delayed (D) prevention of CINV, with significant differences in complete control between the guideline adherent group (GAG) and the guideline nonadherent group (GNG). Significant differences in the FLIE score were noticed between GAG(D) and GNG(D), and GNG(D) had a higher incidence of diarrhoea, headache, swallowing difficulties and dark-coloured stool. Conclusion Consistency with guidelines resulted in significant reduction in the incidence of both cute and delayed CINV and other side effects, and with improvement of the patient quality of life.


Adverse drug reaction Chemotherapy Guideline Nausea Quality of life Vomiting 



The authors are grateful to Merve Sarı who assisted in identifying patients.



Conflicts of interest

The authors have no conflicts of interest to declare.

Supplementary material

11096_2016_393_MOESM1_ESM.docx (59 kb)
Supplementary material 1 (DOCX 58 kb)


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Copyright information

© Springer International Publishing 2016

Authors and Affiliations

  1. 1.Department of Clinical Pharmacy, School of PharmacyIstanbul Kemerburgaz UniversityIstanbulTurkey
  2. 2.Department of Clinical Pharmacy, School of PharmacyMarmara UniversityIstanbulTurkey
  3. 3.Department of Internal Medicine, Division of Medical Oncology, School of MedicineMarmara UniversityIstanbulTurkey
  4. 4.Molecular Medicine Department, Division of Hospital ManagementMarmara University Pendik Training and Research HospitalIstanbulTurkey

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