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International Journal of Clinical Pharmacy

, Volume 37, Issue 3, pp 436–438 | Cite as

Large discrepancies in linezolid use between French teaching hospitals: A comment on “Antimicrobial stewardship and linezolid”

  • G. G. AubinEmail author
  • D. Boutoille
  • S. Corvec
  • J. Caillon
  • A. Caillaud
  • F. Moal
  • D. Navas
Letter to the Editor
  • 185 Downloads

Dear Editor,

We read with great interest in a recent issue of the International Journal of Clinical Pharmacy the article by Guillard et al. [ 1]. In this study, they stated that linezolid was used inappropriately in 40 % of cases in their hospital. We would like to discuss their results in light with a recent observational prospective study that we led in two large teaching hospitals: Nantes University Hospital (Hôtel-Dieu and Mother and Children’s sites) and Angers University Hospital, during a 6-month period in 2012. Each hospital included intensive care, dermatology, hematology, emergency, infectious disease (ID), pediatric, surgical and gynecology-obstetrics units, allowing comparison to Caen data. All prescriptions of linezolid were included. A data-collection card was created and completed using the patients’ medical files, prescriptions collected by the pharmacy and patients’ computerized files. Major results are shown in Table  1. Although linezolid use was mostly off-label in...

Keywords

Vancomycin Linezolid Methicillin Antimicrobial Stewardship Microbiological Result 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Guillard P, de La Blanchardière A, Cattoir V, Fischer M-O, Verdon R, Saint-Lorant G. Antimicrobial stewardship and linezolid. Int J Clin Pharm. 2014;36:1059–68.CrossRefPubMedGoogle Scholar
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    Wunderink RG, Niederman MS, Kollef MH, Shorr AF, Kunkel MJ, Baruch A, et al. Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study. Clin Infect Dis. 2012;54:621–9.CrossRefPubMedGoogle Scholar
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    Boselli E, Breilh D, Rimmelé T, Djabarouti S, Toutain J, Chassard D, et al. Pharmacokinetics and intrapulmonary concentrations of linezolid administered to critically ill patients with ventilator-associated pneumonia. Crit Care Med. 2005;33:1529–33.CrossRefPubMedGoogle Scholar
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    Aubin G, Lebland C, Corvec S, Thomaré P, Potel G, Caillon J, et al. Good practice in antibiotic use: what about linezolid in a French university hospital? Int J Clin Pharm. 2011;33:925–8.CrossRefPubMedGoogle Scholar
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Copyright information

© Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie 2015

Authors and Affiliations

  • G. G. Aubin
    • 1
    • 2
    Email author
  • D. Boutoille
    • 2
    • 3
  • S. Corvec
    • 1
    • 2
  • J. Caillon
    • 1
    • 2
  • A. Caillaud
    • 1
    • 5
  • F. Moal
    • 4
  • D. Navas
    • 2
    • 5
  1. 1.Service de Bactériologie-Hygiène HospitalièreNantes University HospitalNantes Cedex 01France
  2. 2.Laboratoire UPRES EA3826, Thérapeutiques Cliniques et Expérimentales des InfectionsNantes Medicine SchoolNantes Cedex 01France
  3. 3.Service de Maladies Infectieuses et TropicalesNantes University HospitalNantes Cedex 01France
  4. 4.Service de PharmacieAngers University HospitalAngersFrance
  5. 5.Service de PharmacieNantes University HospitalNantes Cedex 01France

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