International Journal of Clinical Pharmacy

, Volume 36, Issue 2, pp 264–267 | Cite as

Unexplained chronic leukopenia treated with oral iron supplements

  • Ayman Abuirmeileh
  • Anas Bahnassi
  • Amjad AbuirmeilehEmail author
Case Report


Case A 67-year-old woman known to have iron deficiency anemia and persistent unexplained chronic leukopenia was cared for by our medical center for about 16 years. During this period she was examined thoroughly and diagnosed to have chronic idiopathic neutropenia (also known as chronic benign neutropenia). Her iron deficiency was attributed to nutritional factors and she was non-compliant with her oral iron supplements. The patient fully received her iron supplement medication by nursing staff for two and a half months during an unexpected prolonged hospital stay after her suffering an acute ischemic cerebrovascular accident. An astonishing outcome was that in addition to having her iron deficiency anemia treated, her long-term unexplained neutropenia was also corrected. Conclusion Some patients diagnosed with chronic idiopathic neutropenia and clinically present as having unexplained chronic neutropenia might actually be suffering from a form of not yet described iron deficiency induced neutropenia.


Anemia Iron deficiency Leukopenia Neutropenia Patient adherence 




Conflicts of interest

Each author states no conflict of interest.


  1. 1.
    Galloway R, Mcguire J. Determinants of compliance with iron supplementation: supplies, side effects, or psychology. Soc Sci Med. 1994;39(III):381–90.PubMedCrossRefGoogle Scholar
  2. 2.
    Donadieu J, Fenneteau O, Beaupain B, Mahlaoui N, Chantelot CB. Congenital neutropenia: diagnosis, molecular bases and patient management. Orphanet J Rare Dis. 2011;6:26–54.PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Schneeweiss S, Hasford J, Göttler M, Hoffmann A, Riethling AK, Avorn J. Admissions caused by adverse drug events to internal medicine and emergency departments in hospitals: a longitudinal population-based study. Eur J Clin Pharmacol. 2002;4:285–91.CrossRefGoogle Scholar
  4. 4.
    Lee GR, Foerster J, Lukens J, et al., eds. Wintrobe’s hematology. 10th ed. Baltimore, MD: William and Wilkins; 1999:1836–1888.Google Scholar
  5. 5.
    Capsoni F, Sarzi-Puttini P, Zanella A. Primary and secondary autoimmune neutropenia. Arthritis Res Ther. 2005;7(V):208–14.PubMedCentralPubMedCrossRefGoogle Scholar
  6. 6.
    Mustafa MM, McClain KL. Diverse hematologic effects of parvovirus B19 infection. Pediatr Clin North Am. 1996;43(3):809–21.PubMedCrossRefGoogle Scholar
  7. 7.
    Papadaki HA, Pontikoglou C. Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia. Expert Rev Hematol. 2008;1(II):217–29.PubMedCrossRefGoogle Scholar
  8. 8.
    Lima CS, Paula EV, Takahashi T, Saad ST, Lorand-Metze I, Costa FF, X. Causes of incidental neutropenia in adulthood. Ann Hematol. 2006;85(X):705–9.PubMedCrossRefGoogle Scholar
  9. 9.
    Jhamb R, Kumar A. Iron deficiency anemia presenting as pancytopenia in an adolescent girl. Int J Adolesc Med Health. 2011;23(I):73–4.PubMedGoogle Scholar
  10. 10.
    Kojima H, Hasegawa Y, Shibuya K, Nakazawa M, Yoda Y, Abe T. Chronic idiopathic neutropenia improved by recombinant granulocyte colony stimulating factor. Rinsho Ketsueki. 1990;31:189–93.PubMedGoogle Scholar

Copyright information

© Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie 2013

Authors and Affiliations

  • Ayman Abuirmeileh
    • 1
  • Anas Bahnassi
    • 2
  • Amjad Abuirmeileh
    • 3
    Email author
  1. 1.Internal MedicineIsawiya Medical CenterAmmanJordan
  2. 2.Clinical and Hospital PharmacyFaculty of Pharmacy - Taibah UniversityAl Madinah Al MunawwarahSaudi Arabia
  3. 3.Clinical Pharmacy Department, Faculty of PharmacyAl-Isra UniversityAmmanJordan

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