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Emesis control by aprepitant in children and adolescents with chemotherapy

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Abstract

Background Chemotherapy-induced nausea and vomiting (CINV) is a feared adverse reaction during cancer treatment. Aprepitant has shown to be effective for CINV in adults, but little is known on its effect in pediatrics. So far, the drug is not licensed in this population. Objective To investigate efficacy of aprepitant in children and young adolescents with high or moderate emetogenic courses, with uncontrollable emesis in previous cycles. Method Retrospective, observational study in children and adolescents treated with aprepitant at Ghent University Hospital, Belgium. Antiemetic regimens and emesis control were analyzed. Results Twenty patient charts representing 104 chemotherapy cycles were reviewed. Complete vomiting control was observed in 10 patients (50 %), representing 89/104 (85.6 %) episodes. Incomplete vomiting control was observed in 10 patients (50 %), representing only 15 episodes (14.4 %). Of these episodes with incomplete vomiting control, 6 were in acute phase (40 %), 7 in delayed phase (46.7 %) and 2 in both acute and delayed phase (13.3 %). Conclusion Aprepitant might be effective in preventing or reducing vomiting in children. When combined with standard antiemetics, aprepitant was well tolerated. In attendance of results of on-going international clinical trials, our results encourage us to continue the use of aprepitant after failure of emesis control in previous cycles.

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Acknowledgments

We thank Pauline Belin (Université Claude Bernard, Lyon, France) for excellent assistance in analyzing the majority of the data.

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There are no conflicts of interest.

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Authors and Affiliations

  1. Department of Pharmacy, Ghent University Hospital, -1 K12, De Pintelaan 185, 9000, Ghent, Belgium

    Tiene G. M. Bauters & Hugo Robays

  2. Department of Pediatric Hemato-Oncology and Stem Cell Transplantation, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium

    Joris Verlooy, Yves Benoit & Geneviève Laureys

Authors
  1. Tiene G. M. Bauters
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  2. Joris Verlooy
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  3. Hugo Robays
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  4. Yves Benoit
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  5. Geneviève Laureys
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Correspondence to Tiene G. M. Bauters.

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Bauters, T.G.M., Verlooy, J., Robays, H. et al. Emesis control by aprepitant in children and adolescents with chemotherapy. Int J Clin Pharm 35, 1021–1024 (2013). https://doi.org/10.1007/s11096-013-9842-4

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  • DOI: https://doi.org/10.1007/s11096-013-9842-4

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