International Journal of Clinical Pharmacy

, Volume 35, Issue 3, pp 297–302 | Cite as

New and old anti-thrombotic treatments for patients with atrial fibrillation

  • Andrea MessoriEmail author
  • Dario Maratea
  • Valeria Fadda
  • Sabrina Trippoli

Impacts on practice

  • The effectiveness of new oral anticoagulants in atrial fibrillation is extensively being studied, but also innovative medical devices aimed at this disease condition need to be evaluated (e.g. Watchman).

  • Regardless of the type of treatment, the same end-points (stroke or systemic embolism, death from any cause) have been assessed in clinical trials so that meta-analysis techniques can be applied.

  • Our study employed network meta-analysis to synthetise the effectiveness data of warfarin, new oral anticoagulants, and Watchman and showed the potential advantages of the new treatments as well as the economic implications in terms of budget impact.


Patients with non-valvular atrial fibrillation are at risk for stroke and can therefore require chronic treatment. While warfarin has long been the standard of care, the new oral anticoagulants (namely, dabigatran, rivaroxaban, and apixaban) have recently been proposed as an alternative. One advantage of these new...


Atrial fibrillation Budget impact Cost-effectiveness Dabigatran Left atrial appendage closure Network meta-analysis Watchman Oral anticoagulants 




Conflicts of interest



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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Andrea Messori
    • 1
    Email author
  • Dario Maratea
    • 1
  • Valeria Fadda
    • 1
  • Sabrina Trippoli
    • 1
  1. 1.HTA UnitArea Vasta Centro Toscana, ESTAV, Regional Health SystemPratoItaly

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