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Atorvastatin-related rhabdomyolysis and acute renal failure in a genetically predisposed patient with potential drug–drug interaction

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References

  1. SEARCH Collaborative Group, Link E, Parish S, Armitage J, Bowman L, Heath S, Matsuda F, et al. SLCO1B1 variants and statin-induced myopathy–a genomewide study. N Engl J Med. 2008;359(8):789–99.

    Article  PubMed  CAS  Google Scholar 

  2. Hoenig MR, Walker PJ, Gurnsey C, Beadle K, Johnson L. The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort. J Clin Lipidol. 2011;5(2):91–6.

    Article  PubMed  Google Scholar 

  3. Bottorff MB. Statin safety and drug interactions: clinical implications. Am J Cardiol. 2006;97(8A):27C–31C.

    Article  PubMed  CAS  Google Scholar 

  4. Naranjo CA, Busto U, Seller EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239–45.

    Article  PubMed  CAS  Google Scholar 

  5. Meyer UA. Interaction of proton pump inhibitors with cytochromes P450: consequences for drug interactions. Yale J Biol Med. 1996;69(3):203–9.

    PubMed  CAS  Google Scholar 

  6. Zanger UM, Turpeinen M, Klein K, Schwab M. Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Anal Bioanal Chem. 2008;392(6):1093–108.

    Article  PubMed  CAS  Google Scholar 

  7. Desta Z, Zhao X, Shin JG, Flockhart DA. Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet. 2002;41(12):913–58.

    Article  PubMed  CAS  Google Scholar 

  8. Li XQ, Andersson TB, Ahlström M, Weidolf L. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004;32(8):821–7.

    Article  PubMed  CAS  Google Scholar 

  9. Wilffert B, Swen J, Mulder H, Touw D. Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics. From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics. Int J Clin Pharm. 2011;33(1):3–9.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

We thank the employees of the Clinical Institute for Laboratory Diagnosis for their contribution to the manuscript.

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None of the authors of this manuscript had any conflict of interests connected with the conduct of the study.

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Correspondence to Srecko Marusic.

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Marusic, S., Lisicic, A., Horvatic, I. et al. Atorvastatin-related rhabdomyolysis and acute renal failure in a genetically predisposed patient with potential drug–drug interaction. Int J Clin Pharm 34, 825–827 (2012). https://doi.org/10.1007/s11096-012-9717-0

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  • DOI: https://doi.org/10.1007/s11096-012-9717-0

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