Pharmacy World & Science

, Volume 29, Issue 4, pp 350–352 | Cite as

Tuberous sclerosis successfully treated with levetiracetam monotherapy: 18 months of follow-up

  • Savvas S. PapacostasEmail author
  • Eleftherios S. Papathanasiou
  • Panayiota Myrianthopoulou
  • Goula Stylianidou



We present the case of a boy with tuberous sclerosis who was referred for evaluation and treatment of his intractable epileptic seizures, having failed multiple anti-epileptic drug trials. He was subsequently treated with Levetiracetam that was gradually titrated to an effective dose, achieving full suppression of his seizures. Thereafter, his concomitant anti-epileptic drugs were gradually reduced and eventually discontinued. He remained on monotherapy with Levetiracetam, which continued to fully control his seizures. His EEG tracings before and after treatment are presented and compared, showing normalization of the latter.


Levetiracetam appears to be effective in treatment-resistant seizures which are symptomatic to tuberous sclerosis when used adjunctively as well as in monotherapy. This is the first report in the English literature regarding its use and efficacy in this condition.


Levetiracetam Tuberous sclerosis Seizures 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Savvas S. Papacostas
    • 1
    • 2
    Email author
  • Eleftherios S. Papathanasiou
    • 2
  • Panayiota Myrianthopoulou
    • 2
  • Goula Stylianidou
    • 3
  1. 1.Department of NeurologyThe Cyprus Institute of Neurology and GeneticsNicosiaCyprus
  2. 2.Department of NeurophysiologyThe Cyprus Institute of Neurology and GeneticsNicosiaCyprus
  3. 3.Department of PediatricsArch. Makarios III HospitalNicosiaCyprus

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