Skip to main content

Advertisement

SpringerLink
Log in

Extreme thrombocytosis under the treatment by amoxicillin/clavulanate

  • Case Report
  • Published:
Pharmacy World and Science Aims and scope Submit manuscript

Abstract

Amoxicillin/Clavulanate related extreme thrombocytosis during the treatment of pneumonia has never been reported. We present a 54-year-old patient who was admitted due to pneumonia, and was treated with amoxicillin/clavulanate IV and 3-day course of 500 mg azithromycin. Despite clinical and radiological evidence showing that pneumonia improved, thrombocytes increased rapidly. After stopping the antibiotic, the thrombocytes returned gradually to normal. Considering the clinical course, we propose that this extreme thrombocytosis was caused by the administration of amoxicillin/clavulanate. We describe this rare and unique patient and review the literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Frye JL, Thompson DF. Drug-induced thrombocytosis. J Clin Pharm Ther 1993;18:45–48.

    PubMed  CAS  Google Scholar 

  2. Finsterer J, Kotzailias N. Thrombocytosis under ciprofloxacin and tazobactam/piperacillin. Platelets 2003;14:329–331.

    Article  PubMed  CAS  Google Scholar 

  3. Moody SB, Pawlicki KS. Thrombocytosis and hyperkalemia associated with the use of ticarcillin/clavulanic acid. Drug Intell Clin Pharm 1987;21:292–293.

    PubMed  CAS  Google Scholar 

  4. Kristjansson K, Cox F, Taylor L. Ticarcillin/clavulanic acid combination. Treatment of bacterial infections in hospitalized children. Clin Pediatr (Phila) 1989;28:521–524.

    CAS  Google Scholar 

  5. Elliott MA, Tefferi A. Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia. Br J Haematol 2005;128:275–290.

    Article  PubMed  CAS  Google Scholar 

  6. Buss DH, Stuart JJ, Lipscomb GE. The incidence of thrombotic and hemorrhagic disorders in association with extreme thrombocytosis: an analysis of 129 cases. Am J Hematol 1985;20:365–372.

    PubMed  CAS  Google Scholar 

  7. Wiwanitkit V. Extreme thrombocytosis: what are the etiologies? Clin Appl Thromb Hemost 2006;12:85–87.

    Article  PubMed  Google Scholar 

  8. Buss DH, Cashell AW, O’Connor ML, Richards F, Case LD. Occurrence, etiology, and clinical significance of extreme thrombocytosis: a study of 280 cases. Am J Med 1994;96:247–253.

    Article  PubMed  CAS  Google Scholar 

  9. Saathoff AD, Elkins SL, Chapman SW, McAllister SF, Cleary JD. Thrombocytosis during antifungal therapy of candidemia. Ann Pharmacother 2005;39:1238–1243.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan

    Chih-Jen Yang, Jhi-Jhu Hwang, Jen-Yu Hung, Inn-Wen Chong & Ming-Shyan Huang

Authors
  1. Chih-Jen Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jhi-Jhu Hwang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jen-Yu Hung
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Inn-Wen Chong
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ming-Shyan Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ming-Shyan Huang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yang, CJ., Hwang, JJ., Hung, JY. et al. Extreme thrombocytosis under the treatment by amoxicillin/clavulanate. Pharm World Sci 28, 326–328 (2006). https://doi.org/10.1007/s11096-006-9051-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11096-006-9051-5

Keywords

Search

Navigation