Differences in adherence and motivation to HIV therapy—two independent assessments in 1998 and 2002
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The aim of this study was to compare the level of adherence and motivation in two independent cross-sectional samples of HIV-infected patients conducted in 1998 and 2002, and to investigate the relationship between adherence and motivation.
Consecutive HIV-infected patients on treatment at a Swedish clinic were asked to complete an anonymous questionnaire. In 1998, 60 patients participated and in 2002, 53 participated. In 2002, the 9-item Morisky Medication Adherence Scale (MMAS) was added to the questionnaire set.
Main outcome measure
Self-reported adherence and motivation.
In 1998, 28.1% of the respondents were considered adherent, while the corresponding proportion was 57.4% in 2002 (P = 0.002). The mean summary score for MMAS was 10.7 in 2002 (13 = perfect adherence). The proportion considered motivated were 22.4% in the 1998 survey and 41.3% in 2002 (P = 0.038). Of the respondents considered motivated in the 2002 survey, 46.7% scored the maximum summary score on the MMAS, while 8.7% of the non-motivated respondents did so (P = 0.016).
The respondents in 2002 were more adherent and motivated than the respondents in 1998 and a relationship between motivation and adherence was found. The difference in adherence and motivation might be due to a new treatment model at the clinic.
KeywordsAcquired immunodeficiency syndrome AIDS HIV Highly active antiretroviral therapy MMAS Patient adherence Patient compliance Patient motivation Pharmacotherapy Sweden
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We thank the following people for their assistance: Colleagues at the HIV clinic, Karolinska University Hospital – Huddinge and also the colleagues at the Department of Pharmacy, Uppsala University. Supported by the Lennhof foundation, Swedish Pharmaceutical Academy, the Department of Infectious Diseases at Karolinska University Hospital – Huddinge and Hospital Pharmacy, Huddinge University Hospital. Potential conflicts of interest: none declared.
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