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Progress in Intradermal and Transdermal Gene Therapy with Microneedles

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Abstract

Gene therapy is one of the most widely studied treatments and has the potential to treat a variety of intractable diseases. The skin's limited permeability, as the body's initial protective barrier, drastically inhibits the delivery effect of gene medicine. Given the potential adverse effects and physicochemical features of the medications, improving generic drug penetration into the skin barrier and achieving an effective level of target tissues remains a challenge. Microneedles have made tremendous improvements in aided gene transfer and medication delivery as a unique method. Microneedles offer the advantage of being minimally invasive and painless, as well as the ability to distribute gene medicines straight through the stratum corneum. Microneedles have been used to penetrate skin tissue with various nucleic acids and medicines in recent years, allowing for a wide range of applications in the treatment of skin ailments. This review focuses on skin-related disorders and immunity, and it primarily discusses the progress of microneedle transdermal gene therapy in recent years. It also complements the current major vectors and related microneedle gene therapy applications.

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Acknowledgements

We thank the National Natural Science Foundation of China (82003670), Science & Technology Support Program of Changzhou (CJ20200075), Natural Science Foundation of Jiangsu (BK20190566), the Starting Scientific Research of Changzhou University (ZMF19020383), Postgraduate Research & Practice Innovation Program of Jiangsu Province (SJCX22_1449).

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Authors and Affiliations

  1. School of Pharmacy, Changzhou University, Changzhou, 213164, People’s Republic of China

    Ting Zhu, Wenya Zhang, Pengju Jiang, Shuwen Zhou, Cheng Wang, Lin Qiu, Pengfei Cui & Jianhao Wang

  2. Wujin Hospital Affiliated With Jiangsu University, Changzhou, 213017, Jiangsu, People’s Republic of China

    Honglei Shi

  3. The Wujin Clinical College of Xuzhou Medical University, Changzhou, 213017, Jiangsu, People’s Republic of China

    Honglei Shi

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  1. Ting Zhu
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Ting Zhu, Pengfei Cui, Jianhao Wang contributed to the conception of the work. Ting Zhu, Wenya Zhang wrote the manuscript. Pengju Jiang, Shuwen Zhou contributed significantly to analysis and manuscript preparation. Lin Qiu revised it critically for important intellectual content. Cheng Wang, Honglei Shi helped perform the analysis with constructive discussions.

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Correspondence to Honglei Shi, Pengfei Cui or Jianhao Wang.

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Zhu, T., Zhang, W., Jiang, P. et al. Progress in Intradermal and Transdermal Gene Therapy with Microneedles. Pharm Res 39, 2475–2486 (2022). https://doi.org/10.1007/s11095-022-03376-x

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