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Ionic Liquids-Based Drug Delivery: a Perspective

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Abstract

Abstract Ionic liquids (ILs) recently draw attention for addressing unmet needs in biomedicines. By converting solids into liquids, ILs are emerging as novel platforms to overcome some critical drawbacks associated with the application of solid or crystalline active pharmaceutical ingredients (APIs). ILs have shown promise in liquidizing or solubilizing APIs, or as green solvents, novel permeation enhancers or active ingredients, alone or synergistically with APIs. Meanwhile, challenges turn up in company with the deepening understanding of ILs as drug delivery carrier systems. This perspective aims to provide a sketchy overview on the status quo with specific attention paid to new problems arising from the utilization of ILs-based technologies in drug delivery.

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Funding

This work is financially supported by Shanghai Municipality Commission of Science and Technology (19XD1400300; 21430760800).

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Authors and Affiliations

  1. Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai, 201203, China

    Yi Lu, Jianping Qi & Wei Wu

  2. Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, China

    Yi Lu, Jianping Qi & Wei Wu

  3. Fudan Zhangjiang Institute, Shanghai, 201203, China

    Yi Lu & Wei Wu

  4. Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China

    Wei Wu

Authors
  1. Yi Lu
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  2. Jianping Qi
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  3. Wei Wu
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Correspondence to Wei Wu.

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Lu, Y., Qi, J. & Wu, W. Ionic Liquids-Based Drug Delivery: a Perspective. Pharm Res 39, 2329–2334 (2022). https://doi.org/10.1007/s11095-022-03362-3

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