Margareta was the referent on my thesis on “the use of intracerebral microdialysis to study blood-brain barrier transport of drugs” that I was to defend in 1993. At that time, microdialysis was the technique that could measure for the first time the concentration time profiles of unbound drugs in animal brain extracellular fluid, while before, at best, concentration time profiles of unbound drugs could be obtained from serial sampling of cerebrospinal fluid from the cisterna magna, or lumbar puncture in human. We started to have discussions on this and it went far more deep into the matter than what I had with others. I was very exited by the profound and open minded attitude by Margareta. This is what I thought science should be like: not being afraid to reconsider existing paradigms, but always keep on looking for the truth.
From that discussion onwards Margareta and we had regular discussions. At a conference on microdialysis in Tenerife (1996) we were standing in the corner with our posters on CNS pharmacokinetics, while all other posters were on neurotransmitters and how these changed by drugs. After a social outing to the volcano we were sitting next to each other in the bus, and Margareta said: lets start organizing our own conference on quantitative microdialysis of drugs. Supported by the LACDR we had our first Symposium on Microdialysis in Drug Research and Development in Noordwijkerhout (NL) in April 1998.
At the Keukenhof in Lisse, during the social event of the 1st Symposium on Microdialysis in Drug Research and Development (the Netherlands, 1997).
This started a community of colleagues (friends) in this research area and many microdialysis symposia would follow, at different locations. This year, 2022, the 9th version is held in Berlin.
At the 4th Symposium on Microdialysis in Drug Research and Development in Vienna (Austria, 2003).
Margareta has been extremely supportive to me (and many others). She is an always listening, interested and helpful person that likes to interact on science as well as on personal aspects. Specifically she stand up for females and the younger ones. She indicated that it would be good for me to go the American Association of Pharmaceutical Scientists Annual meeting in 1997, where later Prof dr Ron Sawchuk (on the photo second left) had started the microdialysis focus group to promote this research area. That became a scientific home, and also further growth.
At the Cerebrovascular Biology Conference in Sendai (Japan, 2011).
With all the research that we did on CNS drug distribution into the brain, all discussions about that, and all the knowledge and insights that we gained, we thought we should teach these lessons learned and In 2010 we started the Annual Course series on the BBB in Drug Research and Development. This is a very successful series of events that, apart from scientific perspectives, also further deepened our friendship.
I have been always inspired by the research Margareta and her team performed. The explicit distinction between Rate and Extent of transport processes and the Combinatory Mapping Approach are important examples of the high quality. Those have served as real game changer in CNS drug research.
Furthermore, with all that she accomplished and what she has been honoured for, Margareta has always remained humble and has been -and still is- an inspiration for the PhD students and postdocs on CNS pharmacology in (also) the Netherlands.