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Pharmacokinetic Advantage of ASD Device Promote Drug Absorption through the Epicardium

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Abstract

Purpose

Due to low therapeutic efficacy and severe adverse reaction of systemic administration for coronary heart disease (CHD) therapy, we designed a novel local target delivery system, called Active hydraulic ventricular Support Drug delivery system (ASD). This study aims to investigate the potential advantages of ASD compared to intrapericardial (IPC) injection and factors affecting drug absorption through epicardium.

Methods

Liposoluble, water soluble and viscous solutions of cyanine 5 (Cy5) fluorescent dye were delivered individually through ASD and IPC in Sprague-Dawley (SD) rats and then tissues were isolated and observed by in vivo imaging system. Atria and ventricles of the heart were taken for the paraffin section and observed under a fluorescence microscope.

Results

The fluorescence intensity of Cy5 injected by ASD distributed in the heart was significantly higher than IPC injection. Whereas, the fluorescence signal spread in other tissues such as lung, liver, spleen, and kidney of ASD groups was much weaker. Moreover, when choosing liposoluble and viscous Cy5, the intensity of the heart turned stronger and fluorescence dye distributed in other tissues was lesser.

Conclusions

The application of ASD device may provide a promising route of drug delivery for CHD. Furthermore, increasing viscosity of the solution and liposolublity of the drug was beneficial to facilitate drug absorption through the epicardium.

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Funding

This study is sponsored by the National Nature Science Foundation of China (grant numbers 30973003 & 30901993) and Qing Lan Project of Jiangsu Province, China.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Jiangsu, 211198, Nanjing, People’s Republic of China

    Reyaj Mikrani, Cunyu Li, Muhammad Naveed, Cuican Li, Qin Zhang, Juanjuan Peng, Lingzhi Zhao & Xiaohui Zhou

  2. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, 3052, Victoria, Australia

    Reyaj Mikrani

  3. School of Pharmacy , Nanjing Medical University , Jiangsu, Nanjing, People’s Republic of China

    Muhammad Naveed

  4. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu, 210023, Nanjing, People’s Republic of China

    Mirza Muhammad Faran Ashraf Baig

  5. School of Sciences, Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Jiangsu Province, 211198, Nanjing, China

    Yue Wang

  6. Department of Surgery, Zhongda Hospital affiliated to Southeast University, Jiangsu Province, 210017, Nanjing, People’s Republic of China

    Xiaohui Zhou

  7. Department of Surgery, Nanjing Shuiximen Hospital, Jiangsu, 210017, Nanjing, People’s Republic of China

    Xiaohui Zhou

Authors
  1. Reyaj Mikrani
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  2. Cunyu Li
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  3. Muhammad Naveed
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  4. Cuican Li
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  5. Mirza Muhammad Faran Ashraf Baig
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  6. Qin Zhang
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  7. Yue Wang
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  8. Juanjuan Peng
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  9. Lingzhi Zhao
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  10. Xiaohui Zhou
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Corresponding author

Correspondence to Xiaohui Zhou.

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All authors declare no conflict of interest.

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Reyaj Mikrani and Cunyu Li are co-first authors

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Mikrani, R., Li, C., Naveed, M. et al. Pharmacokinetic Advantage of ASD Device Promote Drug Absorption through the Epicardium. Pharm Res 37, 173 (2020). https://doi.org/10.1007/s11095-020-02898-6

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  • DOI: https://doi.org/10.1007/s11095-020-02898-6

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