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Sustainable Dissolution Performance of a Carrier Tailored Electrospun

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Abstract

Purpose

This study aims to conduct an impact investigation in the hydrophobic-hydrophilic balance as an important factor for dissolution improvement of a hydrophilic carrier-based solid dispersion system.

Methods

Polymeric carriers with different hydrophobic to hydrophilic ratios were used to prepare several electrospun solid dispersion formulations. Physicochemical properties and surface morphology of the samples were assessed using Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR), polarized light microscopy, Differential Scanning Calorimetry (DSC), X-ray Powder Diffraction (XRPD) and Scanning Electron Microscopy (SEM). Dissolution study was conducted in a non-sink condition to assess the drug release.

Results

Incorporation of a higher amount of hydrophilic component showed an improvement in formulating a fully amorphous system based on XRPD, yet the dissolution rate increment showed no significant difference from the lower. Hence, the degree of crystallinity is proven not to be the crucial factor contributing to dissolution rate improvement. The presence of a concomitant hydrophobic component, however, showed ability in resisting precipitation and sustaining supersaturation.

Conclusion

Hydrophobicity in a binary carrier system plays an important role in achieving and maintaining the supersaturated state particularly for an amorphous solid dispersion.

Graphical Abstract

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Acknowledgments and Disclosures

The authors acknowledge the financial support received from the grant 203/PFARMASI/6711686, Fundamental Research Grant Scheme (FRGS) Malaysia in carrying out this work. The authors would like to express their gratitude to Emeritus Prof. Dr. Yuen Kah Hay in providing the instrumental accessibility used in this study. The authors would like to thank Mr. Edward Tan Kong Weng for the proofreading service.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia

    Xin-Yi Teoh, Yuyu Yeoh, Lai-Keng Yoong & Siok-Yee Chan

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  1. Xin-Yi Teoh
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  2. Yuyu Yeoh
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  3. Lai-Keng Yoong
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  4. Siok-Yee Chan
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Correspondence to Siok-Yee Chan.

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Teoh, XY., Yeoh, Y., Yoong, LK. et al. Sustainable Dissolution Performance of a Carrier Tailored Electrospun. Pharm Res 37, 28 (2020). https://doi.org/10.1007/s11095-019-2734-0

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  • DOI: https://doi.org/10.1007/s11095-019-2734-0

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