Correction to: Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers

The Original Article is available

Correction to: Pharm Res (2018) 35: 138

https://doi.org/10.1007/s11095-018-2416-3

There was a miscalculation of coproporphyrin I AUC0-24h in the published article (Volume 35, Number 7). After the correction of AUC0-24h, AUC ratio and R-square were re-calculated. Then, following corrections were made in the abstract, the body, Fig. 3, Fig. 4 and Table 2 in this article. The interpretation of data in this article was not influenced.

The corrected sentences are below.

Page 1.

Abstract

line 20: coproporphyrin I (r2 = 0.78).

line 23: (r2 = 0.48–0.70).

Page 5.

Effect of Rifampicin on the Plasma Concentrations of Coproporphyrin I.

line 4: 2.3- and 3.5-times higher.

Correlations between the AUC0–24h of Endogenous OATP1B Substrates, and of these with the AUC0–24h of Atorvastatin.

line 6: coproporphyrin I (r2 = 0.78).

line 8: atorvastatin (r2 of 0.65, 0.70 and 0.48, respectively).

The corrected Figures and Table appears below.

Page 9.

figure1

Fig. 3e

Page 10.

Table 2, line 6 Coproporphyrin I.

Probe drug Control +P +RIF300 Fold changea +RIF600 Fold changea
Coproporphyrin I nd 16.8 ± 1.6 38.1 ± 2.7** 2.3 ± 0.1 57.8 ± 3.8**,†† 3.5 ± 0.1
figure2

Fig. 4 a Correlation between AUC0-24h of GCDCA-S and CP-I. b Correlation between AUC0-24h of CP-I and atorvastatin

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Correspondence to Hiroyuki Kusuhara.

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The online version of the original article can be found at https://doi.org/10.1007/s11095-018-2416-3

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Takehara, I., Yoshikado, T., Ishigame, K. et al. Correction to: Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers. Pharm Res 36, 55 (2019). https://doi.org/10.1007/s11095-019-2585-8

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