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Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid

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Abstract

Purpose

The electrospun polymer ultrafine fiber meshes wereused to co-deliver dexamethasone (DEX) and green tea polyphenols (GTP) in order to acquire a suitable balance between effective treament of keloid and safety to the skin.

Methods

This co-delivery system was prepared with a simple electrospinning technology. Keloid model was established on the back of athymic nude mice with the human keloid tissues and the formulated fiber meshes were applied onto keloids for an in vivo evaluation on their therapeutic effects.

Results

Unlike other therapeutic formulations, these fiber meshes as a new surgical dressing possess multiple useful functions, including the capabilities of maintaining a moist environment, resisting bacterial infection and controlling the drug release. Hydrophobic DEX molecules inside the fiber meshes can be released successfully from the channels formed by the early release of the hydrophilic GTP molecules and then transported across the skin. A distinctive result acquired from histological analysis shows that after 3-month treatment, the DEX/GTP-loaded fiber meshes significantly induce the degradation of collagen fibers in keloid on the back of nude mice compared to the traditional treatment.

Conclusion

The dressing formulation based on nanofibers provides a promising platform for the treatment of keloid.

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Acknowledgments And Disclosures

Jinrong Li and Rong Fu are co-first authors. This work was partially supported by National Basic Research Program of China (973 Program, 2012CB933600), National Natural Science Foundation of China (No.30970723 and No.51173150), National Key Project of Scientific and Technical Supporting Programs Funded by MSTC (2012BAI17B06), Key Project in the Science and Technology Pillar Program from Sichuan Science and Technology Bureau (2102SZ0076) and Fundamental Research Funds for The Central Universities (SWJTU11ZT10). We are grateful to Prof. X.D. Li in Sichuan University for kindly providing GTP, and to Prof. Y.P. Chen for valuable discussion.

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Authors and Affiliations

  1. Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science & Engineering, Southwest Jiaotong University, Chengdu, 610031, People’s Republic of China

    Long Li, Guang Yang & Shaobing Zhou

  2. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, People’s Republic of China

    Jinrong Li, Shan Ding & Shaobing Zhou

  3. Plastic Surgery Department, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, 610212, People’s Republic of China

    Rong Fu & Zhendong Zhong

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  1. Jinrong Li
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  2. Rong Fu
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  3. Long Li
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  4. Guang Yang
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Correspondence to Shaobing Zhou.

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Li, J., Fu, R., Li, L. et al. Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid. Pharm Res 31, 1632–1643 (2014). https://doi.org/10.1007/s11095-013-1266-2

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  • DOI: https://doi.org/10.1007/s11095-013-1266-2

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