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Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging

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ABSTRACT

Gene therapy is becoming a promising strategy to treat various kinds of genetic and acquired diseases. However, the development of safe, efficient, and targetable gene delivery systems remains a major challenge in gene therapy. The unique material characteristics of magnetic nanoparticles (MNPs), including high surface area, facile surface modification, controllable size, and excellent magnetic properties, make them promising candidates for gene delivery. The engineered MNPs with modifiable functional surfaces and bioactive cores can result in several advantageous diagnostic and therapeutic properties including enhanced magnetic resonance imaging (MRI) signal intensity, long permeation and retention in the circulatory system, specific delivery of therapeutic genes to target sites. In this review, the updated research on the preparation and surface modification of MNPs for gene delivery is summarized.

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ACKNOWLEDGMENTS AND DISCLOSURES

This work was supported by the Major State Basic Research Development Program of China (973 Program) (2010CB934601, 2013CB733802); the National Nature Science of Foundation of China (NSFC) (81101101, 51273165, 51125001, 51172005); the Research Fellowship for International Young Scientists of the National Natural Science Foundation of China (51250110078); Fundamental Research Funds for the Central Universities (2013121039); and the Key Project of Chinese Ministry of Education (212149).

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Authors and Affiliations

  1. Department of Materials Science and Engineering College of Engineering, Peking University, Beijing, 100871, China

    Ruijun Xing, Jinghan Zhu & Yanglong Hou

  2. Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University, Xiamen, 361102, China

    Gang Liu

  3. Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong, 637007, China

    Gang Liu

  4. Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland, 20892, USA

    Xiaoyuan Chen

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  1. Ruijun Xing
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  2. Gang Liu
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  3. Jinghan Zhu
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  4. Yanglong Hou
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  5. Xiaoyuan Chen
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Correspondence to Gang Liu or Yanglong Hou.

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Xing, R., Liu, G., Zhu, J. et al. Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging. Pharm Res 31, 1377–1389 (2014). https://doi.org/10.1007/s11095-013-1205-2

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  • DOI: https://doi.org/10.1007/s11095-013-1205-2

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