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Physicochemical Interactions in Solid Dosage Forms

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Abstract

Complete characterization and mechanistic understanding of physicochemical interactions in solid dosage forms are not only important for consistent manufacturability, stability, and bioavailability of the drug product, but are also expected under the quality-by-design paradigm of drug development. Lack of this understanding can impact successful and timely development, scale-up, and commercial manufacture of dosage forms. This article highlights the stability and bioavailability implications of physicochemical interactions in dosage forms citing a couple of examples where such interactions necessitated the recall of commercial drug products.

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Authors and Affiliations

  1. Drug Product Science and Technology Bristol-Myers Squibb, Co., One Squibb Dr., P.O. Box 191, New Brunswick, New Jersey, 08903-0191, USA

    Ajit S. Narang, Divyakant Desai & Sherif Badawy

Authors
  1. Ajit S. Narang
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  2. Divyakant Desai
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  3. Sherif Badawy
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Correspondence to Ajit S. Narang.

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Narang, A.S., Desai, D. & Badawy, S. Physicochemical Interactions in Solid Dosage Forms. Pharm Res 29, 2635–2638 (2012). https://doi.org/10.1007/s11095-012-0867-5

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  • DOI: https://doi.org/10.1007/s11095-012-0867-5

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