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Inorganic-Organic Magnetic Nanocomposites for use in Preventive Medicine: A Rapid and Reliable Elimination System for Cesium

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Abstract

Purpose

To investigate the potential use of Prussian blue-coated magnetic nanoparticles, termed “Prussian blueberry”, to bring about the magnetic elimination of cesium.

Methods

Prussian blueberry were prepared by a layer-by-layer assembly method. The morphology, structure and physical properties of the Prussian blueberry were investigated as was their ability to magnetically eliminate cesium.

Results

We confirmed that Prussian blueberry were composed of a magnetite nanoparticle-core and a Prussian blue-shell. Under a magnetic field, Prussian blueberry (5 mg) reduced the cesium concentration of seawater (3 ml) from 150 ppm to about 50 ppm; but regular Prussian blue could not magnetically eliminate cesium. Moreover, Prussian blueberry removed a similar proportion of cesium from a larger volume of seawater, and from fetal bovine serum and cow’s milk.

Conclusions

Under a magnetic field, Prussian blueberry was able to rapidly eliminate cesium from seawater and from biological matrices such as serum and milk.

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Acknowledgments & Disclosures

We dedicate this work to the late T. Terada, the late K. Nariai, and the many people who suffered in the March 11 disaster. We would like to acknowledge the staff of our respective institutes for their assistance. This work was supported by a Funding Program for the Next Generation of World-Leading Researchers (LS114) from the JSPS and by an Industrial Technology Research Grant (08C46049a) from the NEDO of Japan. The authors also wish to thank Mr. C.W.P. Reynolds, associated with the Department of International Medical Communications of Tokyo Medical University, for his careful and detailed assistance with the English of this paper.

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Authors and Affiliations

  1. Institute of Clinical Medicine and Research, The Jikei University School of Medicine, Kashiwa, Japan

    Yoshihisa Namiki, Yukiko Ishii, Yuki Nagase, Akihito Tsubota & Norio Tada

  2. Department of Radiology, The Jikei University School of Medicine, Kashiwa, Japan

    Tamami Namiki

  3. Division of Gastroenterology and Hepatology, The Jikei University School of Medicine, Kashiwa, Japan

    Shigeo Koido

  4. Department of Innovative and Engineered Materials, Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology, Yokohama, Japan

    Yoshitaka Kitamoto

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  1. Yoshihisa Namiki
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  2. Tamami Namiki
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Correspondence to Yoshihisa Namiki.

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Namiki, Y., Namiki, T., Ishii, Y. et al. Inorganic-Organic Magnetic Nanocomposites for use in Preventive Medicine: A Rapid and Reliable Elimination System for Cesium. Pharm Res 29, 1404–1418 (2012). https://doi.org/10.1007/s11095-011-0628-x

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  • DOI: https://doi.org/10.1007/s11095-011-0628-x

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