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Low-Molecular-Weight Methylcellulose-Based Thermo-reversible Gel/Pluronic Micelle Combination System for Local and Sustained Docetaxel Delivery

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ABSTRACT

Purpose

To develop low-molecular-weight methylcellulose (LMw MC)-based gel/Pluronic F127 micelle combination system for local and sustained delivery of docetaxel (DTX).

Methods

LMw MC and Pluronic F127 were used to formulate an injectable thermo-reversible gel/micelle combination system containing DTX. The DTX-loaded combination system was characterized and its therapeutic efficacy evaluated in a subcutaneous tumor model.

Results

Mixtures of LMw MC, AS, and Pluronic F127 formed gel at ~15–40°C depending on AS concentration. The combination system released DTX for >30 days with a biphasic and sustained release pattern, and DTX stability was maintained during release. The combination system significantly enhanced anti-cancer effects of DTX and prolonged survival of the model mouse in comparison with free DTX.

Conclusions

The LMw MC gel/Pluronic F127 micelle combination system constitutes a promising tool for reducing tumor size and eradicating remaining tumor cells before and after surgery.

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ACKNOWLEDGMENTS & DISCLOSURES

This research was partially supported by grants from the Korea Science and Engineering Foundation (20110017022), WCU (World Class University) program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R332010000100360), Yang Young Foundation and Seoul R&BD program (ST100071M093211).

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Authors and Affiliations

  1. Department of Bioengineering, Institute for Bioengineering & Biopharmaceutical Research Hanyang University, 17, Haengdang-dong, Seongdong-gu, Seoul, 133-791, Republic of Korea

    Jang Kyoung Kim, Young-Wook Won, Kwang Suk Lim & Yong-Hee Kim

  2. Institute of Aging Society, Hanyang University, 17, Haengdang-dong, Seongdong-gu, Seoul, 133-791, Republic of Korea

    Yong-Hee Kim

Authors
  1. Jang Kyoung Kim
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  2. Young-Wook Won
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  3. Kwang Suk Lim
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Corresponding author

Correspondence to Yong-Hee Kim.

Additional information

Jang Kyung Kim and Young-Wook Won contributed equally to this work.

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Kim, J.K., Won, YW., Lim, K.S. et al. Low-Molecular-Weight Methylcellulose-Based Thermo-reversible Gel/Pluronic Micelle Combination System for Local and Sustained Docetaxel Delivery. Pharm Res 29, 525–534 (2012). https://doi.org/10.1007/s11095-011-0581-8

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  • DOI: https://doi.org/10.1007/s11095-011-0581-8

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