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Inhalation Performance of Physically Mixed Dry Powders Evaluated with a Simple Simulator for Human Inspiratory Flow Patterns

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ABSTRACT

Purpose

To construct a simple simulator reproducing human inspiratory flow patterns and use it to evaluate the inhalation performance of active ingredient particle-carrier particle systems (physically mixed dry powders).

Methods

Inspiratory flow patterns were collected and analyzed using a flow recorder. The simulator was constructed using an airtight container, a valve, and a connecting tube. Several of the patterns reproduced by the simulator were compared with those recorded. In addition, the influence of inspiratory flow on the inhalation performance of physically mixed dry powders composed of salbutamol sulfate (SS) and coarse lactose monohydrate was investigated using a twin-stage liquid impinger (TSLI) equipped with the simulator.

Results

Human inspiratory flow patterns could be characterized by three parameters: inspiratory flow volume (area under the flow rate-time curve (AUC)), flow increase rate (FIR), and peak flow rate (PFR). The patterns could be reproduced using the simulator. Testing with the simulator in vitro revealed that PFR, but not FIR or AUC, greatly affected the inhalation performance of physically mixed dry powders.

Conclusions

The simulator is simple to construct and can schematically reproduce human inspiratory flow patterns. Testing with a TSLI and the simulator is useful to evaluate dry powder formulations for clinical application.

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Authors and Affiliations

  1. Faculty of Pharmacy, Meijo University, 150 Yagotoyama Tempaku-ku, Nagoya, 468-8503, Japan

    Daiki Hira, Tomoyuki Okuda, Daisuke Kito & Hirokazu Okamoto

  2. Hitachi Automotive Systems, Ltd., 1671-1 Kasukawa-cho Isesaki, Gumma, 372-0023, Japan

    Kazunori Ishizeki & Toyoko Okada

Authors
  1. Daiki Hira
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  2. Tomoyuki Okuda
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  3. Daisuke Kito
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  4. Kazunori Ishizeki
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  5. Toyoko Okada
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  6. Hirokazu Okamoto
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Correspondence to Hirokazu Okamoto.

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Hira, D., Okuda, T., Kito, D. et al. Inhalation Performance of Physically Mixed Dry Powders Evaluated with a Simple Simulator for Human Inspiratory Flow Patterns. Pharm Res 27, 2131–2140 (2010). https://doi.org/10.1007/s11095-010-0215-6

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  • DOI: https://doi.org/10.1007/s11095-010-0215-6

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