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Thermosensitive Micelles from PEG-Based Ether-anhydride Triblock Copolymers

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ABSTRACT

Purpose

The thermosensitive micelles based on the poly(PEG:CPP:SA) terpolymer composed of poly(ethylene glycol) (PEG), 1,3-bis(carboxyphenoxy) propane (CPP) and sebacic acid (SA) were fabricated for application as a promising drug carrier.

Methods

The terpolymer can self-assemble into micelles in water by a precipitation technology. The sol–gel transition behaviors were investigated by the tube-tilting method and dynamic rheology. The drug release behaviors were investigated in phosphate-buffered solution (PBS) at 25, 37 and 45°C, respectively, and the tumor cell growth inhibition assays were also evaluated.

Results

The diameters of these micelles increased as the environmental temperature, and the length of CPP and SA chains increased. The micelles with a low concentration underwent sol-to-nanogel transition as temperature increased from the room temperature to the body temperature, while the polymer solutions with a high concentration underwent sol-to-gel transition as the temperature increased from 20 to 70°C. In vitro release profiles consisted of a burst release followed a sustained release. The cytotoxicity results showed that the terpolymer micelles were biocompatible, and the encapsulated doxorubicin. HCl maintained its potent anti-tumor effect.

Conclusion

These micelles may bring the ether-anhydride family of polymers great potential as a novel carrier in nanomedicine.

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ACKNOWLEDGEMENTS

This work was partially supported by National Natural Science Foundation of China (30970723), Programs for New Century Excellent Talents in university, Ministry of Education of China (NCET-07-0719) and Sichuan Prominent Young Talent Program (08ZQ026-040).

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Authors and Affiliations

  1. Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, People’s Republic of China

    Aijun Zhao, Shaobing Zhou, Qi Zhou & Tao Chen

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  1. Aijun Zhao
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  2. Shaobing Zhou
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  3. Qi Zhou
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  4. Tao Chen
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Correspondence to Shaobing Zhou.

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Zhao, A., Zhou, S., Zhou, Q. et al. Thermosensitive Micelles from PEG-Based Ether-anhydride Triblock Copolymers. Pharm Res 27, 1627–1643 (2010). https://doi.org/10.1007/s11095-010-0155-1

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