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Insights into the Role of Electrostatic Forces on the Behavior of Dry Pharmaceutical Particulate Systems

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Purpose

Under different charging conditions, particles can be either attracted or repulsed by each other, causing powder agglomeration or segregation. Such behavior can be detrimental in many processes aimed at achieving particulate mixture homogeneity. Consequently, the effects of electrostatic charges on mixing kinetics must be well understood to insure a high level of process control, product quality, and reproducibility.

Methods

In Part 1, an electrostatic charger is used to evaluate the ability of the studied particles to develop and retain an induced charge at the surface for a fixed period of time. Part 2 assesses the natural electrostatic charge developed by powders sliding across a stainless steel, plastic, or Tyvek chute. In Part 3, 2 binary systems were formed according to an experimental design under different charging conditions, and their behavior was quantified by measuring the degree of agglomeration attained.

Results

This work has shown that each raw material develops a different charge according to its physico-chemical properties and the type of contact surface. Electrostatic charges influence the creation of agglomerates under certain conditions.

Conclusions

The presence of electrostatic charges must be accounted for in any effort to maximize mixing efficiency.

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Acknowledgments

The authors are indebted to Wyeth Canada Inc. and the Natural Sciences and Engineering Research Council of Canada (NSERC) for financial support. The technical help of Rajendar Abbareddy and the operational assistance of Antoine Cournoyer and Mariève Durand are gratefully acknowledged. Special thanks are due to Ovid DaSilva, Jenny Cleftogiannis, Peter Lanigan, and Sylvie Lebrun for reviewing the manuscript.

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Authors and Affiliations

  1. Department of Chemical Engineering, Faculty of Engineering, Université de Sherbrooke, 2500, boulevard Université, Sherbrooke, Québec, J1K 2R1, Canada

    Emilie DesRosiers Lachiver & Nicolas Abatzoglou

  2. Product and Process Development Technology, Wyeth Canada Inc., Montreal, Québec, Canada

    Emilie DesRosiers Lachiver & Jean-Sébastien Simard

  3. Faculty of Pharmacy, Université de Montréal, Montreal, Québec, Canada

    Louis Cartilier

Authors
  1. Emilie DesRosiers Lachiver
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  2. Nicolas Abatzoglou
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  3. Louis Cartilier
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  4. Jean-Sébastien Simard
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Corresponding author

Correspondence to Nicolas Abatzoglou.

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DesRosiers Lachiver, E., Abatzoglou, N., Cartilier, L. et al. Insights into the Role of Electrostatic Forces on the Behavior of Dry Pharmaceutical Particulate Systems. Pharm Res 23, 997–1007 (2006). https://doi.org/10.1007/s11095-006-9934-0

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  • DOI: https://doi.org/10.1007/s11095-006-9934-0

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