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Testosterone Hormone Replacement Therapy: State-of-the-Art and Emerging Technologies

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Abstract

In the human male, testosterone is the major circulating androgen. The clinical effects of androgen are numerous, and testosterone deficiency is associated with a number of clinical abnormalities. At present, a variety of preparations containing testosterone is available for the treatment of androgen deficiency. Ideally, those treatments have to produce and maintain physiologic serum concentrations of the hormone. This article reviews the current existing testosterone dosage forms on the market with their advantages and drawbacks and examines new and emerging technology developments concerning this therapy. In particular, the latest innovations in transdermal delivery are explored.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, Faculty of Sciences, University of Geneva, CH-1211, Geneva 4, Switzerland

    Marie-Laure Leichtnam & Richard H. Guy

  2. Drug Delivery Research—Formulation Department, Technologie Servier, 45000, Orléans, France

    Marie-Laure Leichtnam, Hervé Rolland & Patrick Wüthrich

  3. Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK

    Richard H. Guy

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  1. Marie-Laure Leichtnam
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Correspondence to Richard H. Guy.

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Leichtnam, ML., Rolland, H., Wüthrich, P. et al. Testosterone Hormone Replacement Therapy: State-of-the-Art and Emerging Technologies. Pharm Res 23, 1117–1132 (2006). https://doi.org/10.1007/s11095-006-0072-5

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