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Design and Evaluation of Celecoxib Porous Particles using Melt Sonocrystallization

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Purpose

The purpose of the article was to study melt sonocrystallization (MSC) for a drug forming a viscous melt when processed below its glass transition temperature.

Methods

A molten mass of drug was poured in a vessel containing deionized water, maintained at 40°C using cryostatic bath, and sonicated for 1 min using probe ultrasonicator at an amplitude of 80% and a cycle of 0.8 per second. The product obtained after solidification of dispersed droplets was separated by filtration and dried at room temperature. MSC celecoxib was characterized by solubility determination, scanning electron microscopy, differential scanning calorimetry, X-ray powder diffraction, and stability study.

Results

The MSC technique was designed for celecoxib, which undergoes fast solidification. The particles obtained by MSC were porous, irregular in shape, and amorphous in nature. An increase in the apparent solubility was observed for the MSC particles. These amorphous particles also exhibited a higher stability in the amorphous state as compared with particles obtained by melt quenching.

Conclusions

The reported MSC technique for celecoxib demonstrates advantages over other approaches and can be exploited in area of particle design for the amorphization of drugs.

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Acknowledgments

AP is thankful to DST and Royal Society for providing a grant under the India–UK Science Network Scheme. AP is also thankful to Mr. Paul Thorning, director of the Institute of Pharmaceutical Innovations, University of Bradford, Bradford, for providing the facilities and Bharati Vidyapeeth Deemed University, Pune, India, for the sabbatical leave. The authors are grateful to Lupin Laboratories (Pune, India) for the sample of celecoxib.

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Authors and Affiliations

  1. Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune-411038, Maharashtra State, India

    Anant Paradkar, Manish Maheshwari & Ravindra Kamble

  2. Institute of Pharmaceutical Innovations, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK

    Ian Grimsey & Peter York

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  1. Anant Paradkar
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  2. Manish Maheshwari
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  3. Ravindra Kamble
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  4. Ian Grimsey
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  5. Peter York
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Correspondence to Anant Paradkar.

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Paradkar, A., Maheshwari, M., Kamble, R. et al. Design and Evaluation of Celecoxib Porous Particles using Melt Sonocrystallization. Pharm Res 23, 1395–1400 (2006). https://doi.org/10.1007/s11095-006-0020-4

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  • DOI: https://doi.org/10.1007/s11095-006-0020-4

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