Features of using the generalized Harrington desirability function for the selection of a binder and lubricant for GML-1 (N-benzyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide) tablets are considered. The factors affecting the characteristics of the finished dosage form are evaluated. Model formulations with different qualitative and quantitative compositions of disintegrant and lubricant excipients were developed. Their pharmaceutical and technological properties were studied. The factors having the greatest impact on indicators such as the mass loss on drying, strength, disintegration, and solubility of the tablets were identified. The type and amount of disintegrant and lubricant in the tablet that could produce a dosage form with the optimal pharmaceutical and technological characteristics were determined.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 58, No. 1, pp. 50 – 55, January, 2024.
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Gavrilov, D.I., Blynskaya, E.V., Tishkov, S.V. et al. Formulating GML-1 Tablets Using the Harrington Desirability Function. Pharm Chem J (2024). https://doi.org/10.1007/s11094-024-03126-w
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DOI: https://doi.org/10.1007/s11094-024-03126-w