Skip to main content
SpringerLink
Log in

The Stability of Azithromycin in a Reconstituted Oral Suspension Under Various In-Home Storage Conditions

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

The stability tests of an active compound or pharmaceutical product provide information about the degradation of the active compound or the deterioration of the pharmaceutical product, which may occur due to various storage conditions—such as high temperature, light and humidity—to which these products may be exposed. The study aimed to investigate the stability of azithromycin in a reconstituted oral suspension under various in-home storage conditions over 10 days. Azithromycin oral suspension was reconstituted by boiled tap water (200 mg/5 ml) and stored under various in-home storage conditions (exposure to sunlight, refrigerated (4°C), stored at room (20°C) and higher temperatures (30°C, 40°C and 50°C). Azithromycin concentrations in the samples of the suspension were analysed daily for 10 days using an HPLC method. The results revealed that the reconstituted azithromycin stored under various in-home storage conditions is stable for 10 days. The active molecule of azithromycin showed good stability after reconstitution with boiled tap water. However, it is necessary to carry out further studies in which the reconstituted oral suspension will be evaluated in terms of the physicochemical and aesthetic appeal (odour, taste, colour and texture) properties of the formulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.

Similar content being viewed by others

References

  1. M. S. Alqahtani, M. Kazi, M. A. Alsenaidy, et al., Front. Pharmacol., 12, 618411 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. A. O. Ebenezer, C. Chioma, and I. M. Omoegbe, J. Pharm. Pharmacol., 5(1), 1 – 6 (2017).

    Google Scholar 

  3. N. Peace, O. Olubukola, and A. Moshood, J. Appl. Pharm. Sci., 2(1), 28 – 31 (2012).

    Google Scholar 

  4. A. K. Y. Alzomor, N. M. Noman, and Y. A. Esmail, Res. J. Life. Sci. Bioinform. Pharm. Chem. Sci., 4(5), 627 – 638 (2018).

    CAS  Google Scholar 

  5. R. J. Al-Ramahi, A. A. N. Zaid, and H. Anabousi, BMC. Res. Notes, 8 (1), 1 – 6 (2015).

    Google Scholar 

  6. B. Kommanaboyina and C. T. Rhodes, Drug. Dev. Ind. Pharm., 25(7), 857 – 868 (1999).

    Article  CAS  PubMed  Google Scholar 

  7. K. S. Kiyingi and J. A. Lauwo, World Health Forum, 14(4), 381 – 384 (1993).

    CAS  PubMed  Google Scholar 

  8. D. H. Peters, H. A. Friedel, and D. McTavish, Drugs, 44(5), 750 – 799 (1992).

    Article  CAS  PubMed  Google Scholar 

  9. J. A. McCutchan, Int. J. Std. Aids, 7 (1), 34 – 37 (1996).

    Article  PubMed  Google Scholar 

  10. J. Saba, P. Morlat, F. Raffi, et al., Eur. J. Clin. Microbiol. Infect. Dis., 12(11), 853 – 856 (1993).

    Article  CAS  PubMed  Google Scholar 

  11. O. Ruuskanen, Pediatr. Infect. Dis. J., 23(2), 135 – 139 (2004).

    Article  Google Scholar 

  12. A. Bala, R. Kumar, and K. Harjai, J. Med. Microbiol., 60(3), 300 – 306 (2011).

    Article  CAS  PubMed  Google Scholar 

  13. L. B. Bacharier, T. W. Guilbert, D. T. Mauger, et al., JAMA, 314(19), 2034 – 2044 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. S. C. Piscitelli, L. H. Danziger, and K. A. Rodvold, Clin. Pharm., 11(2), 137 – 152 (1992).

    CAS  PubMed  Google Scholar 

  15. J. B. Lo, L. E. Appel, S. M. Herbig, et al., Drug Dev. Ind. Pharm., 35(12), 1522 – 1529 (2009).

    Article  CAS  PubMed  Google Scholar 

  16. G. S. Banker and C. T. Rhodes, in: Modern Pharmaceutics, G. S. Banker, J. Siepmann, and C. Rhodes (eds.), CRC Press, Boca Raton (2002), pp. 1215 – 1242.

  17. S. Singh, Pharm. Technol., 23(6), 68 – 88 (1999).

    Google Scholar 

  18. ICH, Q1A (R2), Stability testing of new drug substances and products, International Conference on Harmonization, Switzerland (2003), pp. 16 – 31.

  19. F. Al-Rimawi and M. Kharoaf, J. Chromatogr. Sci., 48(2), 86 – 90 (2010).

    Article  CAS  PubMed  Google Scholar 

  20. K. Belfield, R. Bayston, J. P. Birchall, et al., Int. J. Pediatr. Otorhino., 79(3), 296 – 300 (2015).

    Article  Google Scholar 

  21. R. Auckenthaler, J. Antimicrob. Chemother., 50(1), 13 – 17 (2002).

    Article  CAS  PubMed  Google Scholar 

  22. W. Naidong, S. Hua, E, Roets, et al., J. Pharm. Biomed. Anal., 33(1), 85 – 93 (2003).

  23. G. Lee, in: Drug Stability, Principles and Practices, J. T. Carstensen and C. T. Rhodes, (eds.), Marcel Dekker, New York (2002), pp. 256 – 257.

  24. A. W. Wong and A. Datla, in: Handbook of Pharmaceutical Analysis by HPLC, S. Ahuja and M. W. Dong (eds.), Academic Press (2005), pp. 335 – 358.

  25. A. D. H. Moreno, M. F. C. D. Silva, and H. R. N. Salgado, Braz. J. Pharm. Sci., 45(2), 219 – 226 (2009).

    Article  CAS  Google Scholar 

  26. M. Roca, M. Castillo, P. Marti, et al., J. Agric. Food. Chem., 58(9), 5427 – 5431 (2010).

    Article  CAS  PubMed  Google Scholar 

  27. A. C. Mehta, S. Hart-Davies, J. Paynet, et al., J. Clin. Pharm. Ther., 19(5), 313 – 315 (1994).

    Article  CAS  PubMed  Google Scholar 

  28. N. Salunke, P. S. Kharkar, and N. Pandita, Biomed. Chromatogr., 33(6), 4489 (2019).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Balikesir University, Faculty of Medicine, Department of Medical Pharmacology, Cagis Campus, Balikesir, 10145, Turkey

    Cengiz Gokbulut, Fazilet Sen & Nurullah Geyguc

  2. Balikesir University, Faculty of Medicine, Cagis Campus, Balikesir, 10145, Turkey

    Omer Faruk Sari

  3. Balikesir University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, CoHE 100/2000 Scholarship Holder, Cagis Campus, Balikesir, 10145, Turkey

    Busra Aslan Akyol

Authors
  1. Cengiz Gokbulut
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Omer Faruk Sari
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Busra Aslan Akyol
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fazilet Sen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nurullah Geyguc
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cengiz Gokbulut.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gokbulut, C., Sari, O.F., Akyol, B.A. et al. The Stability of Azithromycin in a Reconstituted Oral Suspension Under Various In-Home Storage Conditions. Pharm Chem J 57, 1841–1847 (2024). https://doi.org/10.1007/s11094-024-03087-0

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-024-03087-0

Keywords

Search

Navigation