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Some Schiff Bases Containing Eugenol and Guaiacol: Comparison of Urease Inhibition and Anti-Helicobacter pylori Activities with Its Azo Analogs

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Pharmaceutical Chemistry Journal Aims and scope

To improve and develop our monotherapeutic approach for Helicobacter pylori infection, some Schiff base compounds containing eugenol and guaiacol were synthesized and their antioxidant capacities, urease enzyme inhibition, and Anti-Helicobacter pylori effect were investigated and compared with azo analogs in the literature. All Schiff base compounds have been found to have both stronger urease enzyme inhibitory and more effective Anti-Helicobacter pylori properties than its azo analogs. In particular, the antimicrobial effect of Schiff bases containing eugenol increased dramatically when compared to their azo analogs.

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Acknowledgments

This study was supported by the Recep Tayyip Erdoğan University Scientific Research Project Units (Project No: FBA-2020-1107).

Conflict of Interest Statement

The authors declare that there is no conflict of interest.

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Authors and Affiliations

  1. Science and Art Faculty, Chemistry Department, Recep Tayyip Erdoğan University, Rize, Turkey

    Cihan Kantar, Nimet Baltaş & Selami Şaşmaz

  2. Science and Art Faculty, Biology Department, Recep Tayyip Erdoğan University, Rize, Turkey

    Şengül Alpay Karaoğlu

Authors
  1. Cihan Kantar
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  2. Nimet Baltaş
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  3. Şengül Alpay Karaoğlu
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  4. Selami Şaşmaz
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Correspondence to Cihan Kantar.

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Kantar, C., Baltaş, N., Karaoğlu, Ş.A. et al. Some Schiff Bases Containing Eugenol and Guaiacol: Comparison of Urease Inhibition and Anti-Helicobacter pylori Activities with Its Azo Analogs. Pharm Chem J 57, 1738–1744 (2024). https://doi.org/10.1007/s11094-024-03074-5

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  • DOI: https://doi.org/10.1007/s11094-024-03074-5

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