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Modernization of the Synthesis and Anti-Inflammatory Activity of 4,10-di(2-Ethoxyacetyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane – An Innovative Non-Narcotic Analgesic

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Pharmaceutical Chemistry Journal Aims and scope

A modified method for the synthesis of a promising non-narcotic analgesic agent of the hexaazaisowurtzitane class with pronounced anti-inflammatory activity is described. Methods for reducing the cost of the target substance are considered. The physicochemical characteristics are described. The efficacy and safety of the synthesized agent are shown in several animal models.

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Authors and Affiliations

  1. Institute for Problems of Chemical and Energetic Technologies, Siberian Branch, Russian Academy of Sciences (IPCET SB RAS), 1 Sotsialisticheskaya St, Biysk, 659322, Russia

    V. V. Eremina, D. A. Kulagina & S. V. Sysolyatin

  2. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, 3 Prosp. Lenina, Tomsk, 634028, Russia

    S. G. Krylova, E. A. Kiseleva, T. N. Povetyeva, E. P. Zueva, N. I. Suslov & V. V. Zhdanov

Authors
  1. V. V. Eremina
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  2. D. A. Kulagina
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  3. S. G. Krylova
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  4. E. A. Kiseleva
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  5. T. N. Povetyeva
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  6. E. P. Zueva
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  7. N. I. Suslov
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  8. S. V. Sysolyatin
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  9. V. V. Zhdanov
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Corresponding author

Correspondence to D. A. Kulagina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 11, pp. 13 – 19, November, 2023.

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Eremina, V.V., Kulagina, D.A., Krylova, S.G. et al. Modernization of the Synthesis and Anti-Inflammatory Activity of 4,10-di(2-Ethoxyacetyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane – An Innovative Non-Narcotic Analgesic. Pharm Chem J 57, 1703–1708 (2024). https://doi.org/10.1007/s11094-024-03068-3

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  • DOI: https://doi.org/10.1007/s11094-024-03068-3

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