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Mononuclear Metal Complexes of Moxifloxacin with Antacids: Synthesis, Spectroscopic Characterization, and Antimicrobial Activities

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Pharmaceutical Chemistry Journal Aims and scope

Mononuclear metal complexes of 1-cyclopropyl-7-[(S,S)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinoline carboxylic acid (moxifloxacin) with commonly used antacids metal ions have been prepared and studied by physicochemical, elemental analysis and spectroscopic techniques (IR and 1H NMR spectroscopy). In all synthesized metal complexes, moxifloxacin acted as a bidentate deprotonated ligand that bound to the metal through the carbonyl oxygen and one carboxylate oxygen atoms. The complexes were screened against 11 Gram-positive and Gram-negative organisms and also screened against 6 fungi, where moxifloxacin was used as standard. It has been concluded that some of these complexes showed in vitro growth inhibitory activities comparable with or higher than the parent drug.

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References

  1. A. R. Millanao, A. Y. Mora, N. A. Villagra, et al., Molecules, 26(23), 7153 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. K.-M. Deppermann and H. Lode, Drugs, 45(3), 65 – 72 (1993).

    Article  PubMed  Google Scholar 

  3. A. Allen, E. Bygate, H. Faessel, et al., Int. J. Antimicrob. Agents, 15(4), 283 – 289 (2000).

    Article  CAS  PubMed  Google Scholar 

  4. L. Wan, Y. Wu, B. Zhang, et al., J. Hazard. Mater., 409, 124518 (2021).

    Article  CAS  PubMed  Google Scholar 

  5. G. H. Wynn, J. R. Oesterheld, K. L. Cozza, et al., Am. Psychiatr. Pub. (2009).

  6. I. Yousuf, M. Bashir, F. Arjmand, et al., Coord. Chem. Rev., 445, 214104 (2021).

    Article  CAS  Google Scholar 

  7. K. Seku, A. K. Yamala, M. Kancherla, et al., J. Anal. Sci. Technol., 9(1), 1 – 13 (2018).

    Article  Google Scholar 

  8. D. M. Walden, M. Khotimchenko, H. Hou, et al., Pharmaceutics, 13(5), 594 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. N. Sultana, M. Saeed Arayne, and M. Akhtar, JSM Chem., 2(1), 1007 (2014).

  10. I. Turel, Coord. Chem. Rev., 232(1 – 2), 27 – 47 (2002).

    Article  CAS  Google Scholar 

  11. H. S. Elshafie, S. H. Sakr, S. A. Sadeek, et al., Chem. Biodiversity, 16(3), e1800633 (2019).

    Article  Google Scholar 

  12. H. M. Refaat and D. A. N. El-Din, J. Mol. Struct., 1163, 103 – 113 (2018).

    Article  CAS  ADS  Google Scholar 

  13. S. A. Sadeek, W. H. El-Shwiniy, and M. S. El-Attar, Spectrochim. Acta, Part A, 84(1), 99 – 110 (2011).

    Article  CAS  Google Scholar 

  14. N. Sultana, M. S. Arayne, M. Akhtar, et al., J. Chin. Chem. Soc., 57(4A), 708 – 717 (2010).

    Article  CAS  Google Scholar 

  15. M. Akhtar, N. Sultana, M. S. Arayne, et al., Pak. J. Pharm. Sci., 32(3 Special), 1301 – 1306 (2019).

  16. M. Akhtar, N. Sultana, M. S. Arayne, et al., Pak. J. Pharm. Sci., 32(3 (Supplem.)), 1201 – 1206 (2019).

  17. G. B. Deacon, and R. J. Phillips, Coord. Chem. Rev., 33(3), 227 – 250 (1980).

    Article  CAS  Google Scholar 

  18. A. M. Beltagi, J. Pharm. Biomed. Anal., 31(6), 1079 – 1088 (2003).

    Article  CAS  PubMed  Google Scholar 

  19. M. Dolaz, V. McKee, A. Golcu, et al., Curr. Org. Chem., 14(3), 281 – 288 (2010).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan

    Mahwish Akhtar

  2. Department of Pharmacy Iqra University, Karachi, Pakistan

    Muhammad Imran

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  1. Mahwish Akhtar
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  2. Muhammad Imran
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Correspondence to Muhammad Imran.

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Akhtar, M., Imran, M. Mononuclear Metal Complexes of Moxifloxacin with Antacids: Synthesis, Spectroscopic Characterization, and Antimicrobial Activities. Pharm Chem J 57, 1557–1567 (2024). https://doi.org/10.1007/s11094-024-03049-6

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  • DOI: https://doi.org/10.1007/s11094-024-03049-6

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