The goal of this study was an evaluation of the immunomodulatory effect of polysaccharides isolated from the seeds of Brassica rapa. Apolysaccharide (BRP) consisting mainly of α-linked pyranose residues belonging to the arabinogalactan class was obtained. The number of antibody-forming cells (AFCs) per spleen increased to 9,160 ± 1477.06, 12,000 ± 3480.33, and 19,080 ± 12,391.6 [antibody-forming reaction index (ARI) = 1, 5, 2, and 3.2 times, respectively] in experimental mice treated with BRP at a dose of 0.05, 0.5, and 5 mg/kg, respectively. The number of AFCs was 70.8 ± 8.05, 73.17 ± 20.5, and 120.3 ± 83.7, respectively, when converted to one million spleen cells. Under the effect of BRP at all studied doses (0.05, 0.5, and 5 mg/kg), a dose-dependent decrease in the index of response to inflammation was observed and a significant trend toward a decrease in the development of hypersensitivity reactions of the delayed type was revealed, especially at doses of 0.5 and 5 mg/kg, as compared to a reference drug (Immunal) administered at a dose of 60 mg/kg. The results suggested that B. rapa polysaccharides had a stimulating effect on the humoral and cellular immune response.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 10, pp. 22 – 26, October, 2023.
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Abdugafurova, D.G., Oripova, M.Z., Amanlikova, D.A. et al. Study of the Immunomodulatory Effect of Polysaccharides Isolated from Seeds of Turnip BRASSICA RAPA. Pharm Chem J 57, 1552–1556 (2024). https://doi.org/10.1007/s11094-024-03048-7
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DOI: https://doi.org/10.1007/s11094-024-03048-7