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Effect of Dimethylsulfoxide on the Nociceptive Response Induced by TRPV1 Ion-Channel Stimulation in Mice

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The effect of preventive administration of a single intraperitoneal dose of dimethylsulfoxide (DMSO) at various concentrations (10, 30 and 50%; 10 mL/kg) on the nociceptive response in mice induced by local and systemic activation of TRPV1 ion channels by the TRPV1 agonist capsaicin was studied. DMSO (50%) significantly reduced (by 73.1%) the latency of the response to injection of capsaicin solution into the metatarsus. DMSO in the tail-flick test did not significantly affect the thermal pain threshold, which was elevated after a single subcutaneous injection (above the shoulder blades) of capsaicin at a dose of 1 mg/kg. However, DMSO (30 and 50%) per se raised the pain threshold of mice in the tail-flick test. Because externally applied DMSO enhanced the effect of capsaicin in the capsaicin test, the demonstrated analgesic effect of a single intraperitoneal injection of DMSO in the capsaicin test and tail-flick test in mice was due to its central action rather than to its effect on afferent innervation.

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Authors and Affiliations

  1. Research Zakusov Institute of Pharmacology, 8 Baltiiskaya St., Moscow, 125315, Russia

    E. A. Ivanova, S. K. Mamonova & T. A. Voronina

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  1. E. A. Ivanova
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  2. S. K. Mamonova
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  3. T. A. Voronina
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Correspondence to E. A. Ivanova.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 8, pp. 15 – 19, August, 2023.

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Ivanova, E.A., Mamonova, S.K. & Voronina, T.A. Effect of Dimethylsulfoxide on the Nociceptive Response Induced by TRPV1 Ion-Channel Stimulation in Mice. Pharm Chem J 57, 1159–1163 (2023). https://doi.org/10.1007/s11094-024-03021-4

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