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Lipophilic Imidazolylpyridines with Antimicrobial Activity

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The reaction of nicotinic and isonicotinic propargylamides with lipophilic aliphatic amines yielded a series of 3- or 4-(5-methyl-1H-imidazol-2-yl)pyridines containing a lipophilic substituent in the imidazole ring 1-position. The new compounds were characterized by physicochemical methods. The antituberculosis and antimicrobial activities against ESKAPE pathogens were studied. 3-[1-(1-n-Octadecyl)-5-methyl-1Himidazol-2-yl]pyridine (IIId) had antituberculosis activity (MIC 6.2 μg/mL) while 3-[1-(1-adamantylmethyl)-5-methyl-1H-imidazol-2-yl]pyridine (IIIa) exhibited activity against S. aureus (MIC 16 μg/mL).

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Authors and Affiliations

  1. Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, 1a Malaya Pirogovskaya, Moscow, 119435, Russia

    T. S. Vedekhina

  2. St. Petersburg State Research Institute of Phthisiopulmonology, Ministry of Health of Russia, 2 – 4 Ligovskii Prosp., St. Petersburg, 191036, Russia

    M. Z. Dogonadze & T. I. Vinogradova

  3. Lomonosov Institute of Fine Chemical Technologies, MIREA – Russian Technological University, 86 Prosp. Vernadskogo, Moscow, 119571, Russia

    M. V. Chudinov & A. Yu. Lukin

Authors
  1. T. S. Vedekhina
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  2. M. Z. Dogonadze
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  3. T. I. Vinogradova
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  4. M. V. Chudinov
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  5. A. Yu. Lukin
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Corresponding author

Correspondence to T. S. Vedekhina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 6, pp. 18 – 23, June, 2023.

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Vedekhina, T.S., Dogonadze, M.Z., Vinogradova, T.I. et al. Lipophilic Imidazolylpyridines with Antimicrobial Activity. Pharm Chem J 57, 816–821 (2023). https://doi.org/10.1007/s11094-023-02954-6

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  • DOI: https://doi.org/10.1007/s11094-023-02954-6

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