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Essential Oils from Traditional Medicinal Plants in Malaysia: A Review on Their Traditional Uses, Bioactive Constituents and Therapeutic Potential

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Pharmaceutical Chemistry Journal Aims and scope

Malaysia, a Southeast Asian country, is well known for its tropical rainforest. Malaysia has approximately 15,000 species of vascular plants. Among these, 2,000 plant species are estimated to possess medicinal values. Medicinal plants have promising therapeutic potential in treating certain illnesses and health disorders. They have been regarded as an important source of drugs and/or therapeutic agents. Essential oils (EOs), or known as aromatic oils, are a complex mixture of volatile chemical constituents extracted from various parts of plants. Over the years, EOs are gaining wide attention from the scientific community owing to their broad spectrum of pharmacological activities. To date, EOs are extensively used in flavour and fragrance, food and pharmaceutical industries. The present review focused on the traditional medicinal plants from Malaysia along with the extracted EOs, major chemical constituents and potent pharmacological activities. This review serves as an important reference for the discovery and developments of bioactive EOs from traditional medicinal plants.

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References

  1. N. Adnan and N. Othman, Procedia Soc. Behav. Sci., No. 42, 231 – 241 (2012).

  2. M. Ozturk, V. Altay, A. Latiff, et al., in: Plant and Human Health, M. Ozturk and K. Hakeem (eds.), Springer Cham, Copenhagen (2018), Vol. 1, pp. 409 – 461.

  3. K. H. D. Tang, Sci. Total Environ., No. 650, 1858 – 1871 (2019).

  4. M. N. Normah, in: Encyclopedia of Food Sciences and Nutrition (Second Edition), B. Caballero (eds.), Academic Press, Massachusetts (2003), pp. 2816 – 2820.

  5. J. J. M. Miranda, in: Phytomedicine, R. A. Bhat, K. R. Hakeem, M. A. Dervash (eds.), Academic Press, Massachusetts (2021), pp. 207 – 223.

  6. R. Longuet, in: Encyclopaedia of the History of Science, Technology, and Medicine in Non-Western Cultures, H. Selin (eds.), Springer, Dordrecht, (2008), pp. 13 – 38.

  7. J.-L. Rios, in: Essential Oils in Food Preservation, Flavor and Safety, V. R. Preedy (eds.), Academic Press, Massachusetts, (2016), pp. 3 – 10.

  8. B. A. Samling, Z. Assim, W. Y. Tong, et al., Arabian J. Chem., No. 14, 103302 (2021).

  9. F. Anwar, K. M. Alkharfy, T. Mehmood, et al., Pharm. Chem. J., 55(2), 187 – 193 (2021).

    Article  CAS  Google Scholar 

  10. K. Y. Liew, M. F. Hafiz, Y. J. Chong, et al., Evidence-Based Complem. Altern. Med., 2020(8257817), 1 – 20 (2020).

    Article  Google Scholar 

  11. S. Saensouk, P. Saensouk, P. Pasorn, et al., Agric. Nat. Resour., 50(6), 445 – 453 (2016).

    Google Scholar 

  12. Y. Sivasothy, C. C. K. Zachariah, K. H. Leong, et al., Tetrahedron Lett., No. 55, 6163 – 6166 (2014).

  13. Y. Sun, M. Kurokawa, M. Miura, et al., in: Studies in Natural Products Chemistry, Atta-ur-Rahman (eds.), Elsevier, Amsterdam, (2016), pp. 157 – 187.

  14. W. J. Kress, A.-Z. Liu, M. Newman, et al., Am. J. Bot., 92(1), 167 – 178 (2005).

    Article  CAS  PubMed  Google Scholar 

  15. Malaysia Biodiversity Information System (MyBIS), Ministry of Energy and Natural Resources (KeTSA), Malaysia (2021). accessed November 2021. https: //www.mybis.gov.my/one/.

  16. F. Abdullah, P. Subramanian, H. Ibrahim, et al., J. Insect Sci., 15(1), 1 – 7 (2015).

    Article  Google Scholar 

  17. L. Zhao, L.-Y. Chen and J.-Y. Liang, Chin. J. Nat. Med., 10(5), 0370 – 0373 (2012).

    CAS  Google Scholar 

  18. P. N. Ravindran, G. S. Pillai and K. N. Babu, in: Handbook of Herbs and Spices, K. V. Peter (eds.), Woodhead Publishing, Sawston, (2004), pp. 53 – 103.

  19. A. Chouni and S. Paul, Pharmacogn J., 10(1), 9 – 15 (2018).

    Article  CAS  Google Scholar 

  20. H. Ibrahim, Y. Sivasothy, D. R. Syamsir, et al., Sci. World J., No. 2014, 1 – 6 (2014).

  21. D. R. Syamsir, N. Tohar, H. Ibrahim H, et al., Sains Malays., 49(1), 43 – 48 (2020).

  22. S. J. T. Lachumy, S. Sasidharan, V. Sumathy, et al., Asian Pac. J. Trop. Med., 3(10), 769 – 774 (2010).

    Google Scholar 

  23. E. W. C. Chan, Y. Y. Lim and M. Omar, Food Chem., No. 104, 1586 – 1593 (2007).

  24. A. F. M. Shahid-Ud-Daula, M. A. A. Kuyah, A. S. Kamariah, et al., S. Afr. J. Bot., No. 121, 45 – 53 (2019).

  25. C. S. Vairappan, T. Nagappan and K. Palaniveloo, Nat. Prod. Commun., 7(2), 239 – 242 (2012).

    CAS  PubMed  Google Scholar 

  26. S. I. Abdelwahab, F. Q. Zaman, A. A. Mariod, et al., J. Sci. Food Agric., No. 90, 2682 – 2668 (2010).

  27. B. Mahdavi, W. A. Yaacob and L. B. Din, Asian Pac. J. Trop. Med., 10(8), 819 – 826 (2017).

    CAS  Google Scholar 

  28. M. K. A. Baharudin, S. A. Hamid and D. Susanti. J. Phys. Sci., 26(1), 71 – 81 (2015).

    Google Scholar 

  29. S. I. Abdelwahab, A. A. Mariod, M. M. E. Taha, et al., Arabian J. Chem., No. 10, 131 – 135 (2017).

  30. N. Azizan, S. M. Said, Z. Z. Abidin, et al., Molecules, No. 22, 2135 (2017).

    Google Scholar 

  31. W.-N. Tan, J.-Q. Lim, F. Afiqah, et al., Nat. Prod. Res., 32(7), 854 – 858 (2018).

    Article  CAS  PubMed  Google Scholar 

  32. W.-N. Tan, K.-C. Wong, M. Khairuddean, et al., Flavour Fragrance J., No. 28, 2 – 9 (2013).

  33. W.-N. Tan, Z.-H. Tan, N. I. Zulkifli, et al., Nat. Prod. Res., 34(23), 3404 – 3408 (2020).

    Article  CAS  PubMed  Google Scholar 

  34. W.-N. Tan, W.-Y. Tong, C.-R. Leong, et al., J. Essent. Oil-Bear. Plants, 23(4), 832 – 842 (2020).

    Article  CAS  Google Scholar 

  35. A. G. S. Humeirah, M. A. N. Azah, M. Mastura, et al., Afr. J. Biotechnol., 9(34), 5511 – 5515 (2010).

    Google Scholar 

  36. W. M. N. H. W. Salleh, F. Ahmad and K. H. Yen, Nat. Prod. Commun., 9(12), 1795 – 1798 (2014).

    Google Scholar 

  37. W. M. N. H. W. Salleh, F. Ahmad, K. H. Yen, et al., Int. J. Mol. Sci., No. 12, 7720 – 7731 (2011).

  38. H. Bagheri, M. Y. B. A. Manap and Z. Solati, Talanta, No. 121, 220 – 228 (2014).

    CAS  Google Scholar 

  39. W. M. N. H. W. Salleh, F. Ahmad, K. H. Yen, et al., Nat. Prod. Commun., 7(12), 1659 – 1662 (2012).

    PubMed  Google Scholar 

  40. R. Ahmad, S. N. Baharum, H. Bunawan, et al., Molecules, No. 19, 19220 – 19242 (2014).

    Google Scholar 

  41. W. M. N. H. W. Salleh, S. Khamis, M. A. Nafiah, et al., Nat. Prod. Res., 35(11), 1887 – 1892 (2021).

    Article  CAS  PubMed  Google Scholar 

  42. W. M. N. H. W. Salleh and S. Khamis, J. Essent. Oil-Bear. Plants, 23(2), 331 – 336 (2020).

    Article  CAS  Google Scholar 

  43. W. M. N. H. W. Salleh and S. Khamis, Riv. Ital. Sostanze Grasse, No. 97, 11 – 16 (2020).

  44. Y. Sivasothy, W. K. Chong, A. Hamid, et al., Food Chem., No. 124, 514 – 517 (2011).

  45. M. R. Sulaiman, T. A. S. T. Mohamad, W. M. S. Mossadeq, et al., Planta Med., No. 76, 107 – 112 (2010).

  46. N. M. Y. Akhtar, I. Jantan, L. Arshad, et al., BMC Complementary Altern. Med., No. 19, 331 (2019).

  47. I. Theilade, Revision of the genus Zingiber in Peninsular Malaysia, The Gardens’ Bull., Singapore, No. 48, 207 – 236 (1998).

  48. K. Srinivasan, PharmaNutrition, No. 5, 18 – 28 (2017).

    Google Scholar 

  49. G. C. L. Ee and Y. L. Cheow, Pertanika J. Sci. & Technol., 15(2), 95 – 102 (2007).

    Google Scholar 

  50. O. Chantarasriwong, A. Batova,W. Chavasiri, et al., Chem. Eur. J., No. 16, 9944 – 9962 (2010).

  51. V. S. Parmar, S. C. Jain, K. S. Bisht, et al., Phytochemistry, 46(4), 597 – 673 (1997).

    Article  CAS  Google Scholar 

  52. M. T. Islam, J. Hasan, H. M. S. H. Snigdha, et al., J. Ethnopharmacol., No. 257, 112853 (2020).

  53. B. Salehi, Z. A. Zakaria, R. Gyawali, et al., Molecules, 24(7), 1364 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  54. Y. Adam, M. N. Somchit, M. R. Sulaiman, et al., J. Ethnopharmacol., No. 124, 154 – 158 (2009).

  55. S. Bhavaniramya, S. Vishnupriya, M. S. Al-Aboody, et al., Grain Oil Sci. Technol., 2(2), 49 – 55 (2019).

    Google Scholar 

  56. A. Kabir, F. Cacciagrano, A. Tartaglia, et al., in: Recent Advances in Natural Products Analysis, A. S. Silva, S. F. Nabavi, M. Saeedi, S. M. Nabavi (eds.), Elsevier, Amsterdam, (2020), pp. 274 – 286.

  57. M. Zielinska-B3ajet and J. Feder-Kubis, Int. J. Mol. Sci., No. 21, 7078 (2020).

  58. N. E. Hachlafi, T. Aanniz, N. E. Menyiy, et al., Food Rev. Int., In Press. DOI:10.1080 / 87559129.2021.1936007 (2021).

  59. B. Salehi, S. Upadhyay, I. E. Orhan, et al., Biomol., No. 9, 738 (2019).

  60. M. Bacanlý, A. A. Baþaran, N. Baþaran, in: Polyphenols: Prevention and Treatment of Human Disease (Second Edition), R. R. Watson, V. R. Preedy, S. Zibadi (eds.), Academic Press, Massachusetts, (2018), pp. 419 – 424.

  61. Y. Cao, H. Zhang, H. Liu, et al., Appl. Microbiol. Biotechnol., No. 102, 1535 – 1544 (2018).

  62. Z.-M. Cai, J.-Q. Peng, Y. Chen, et al., J. Asian Nat. Prod. Res., 23(10), 938 – 954 (2021).

    Article  CAS  PubMed  Google Scholar 

  63. W. Chen and A. M. Viljoen, S. Afr. J. Bot., 76(4), 643 – 651 (2010).

    CAS  Google Scholar 

  64. M. D. Awouafack, P. Tane, V. Kuete, et al., in: Medicinal Plant Research in Africa, V. Kuete (eds.), Elsevier, Amsterdam, (2013), pp. 33 – 103.

  65. J. A. Hartsel, J. Eades, B. Hickory, et al., in: Nutraceuticals, R. C. Gupta (eds.), Academic Press, Massachusetts, (2016), pp. 735 – 754.

  66. U. Neuenschwander, B. Czarniecki and I. Hermans, J. Org. Chem., 77(6), 2865 – 2869 (2012).

    Article  CAS  PubMed  Google Scholar 

  67. S. P. Bhatia, C. S. Letizia and A. M. Api, Food Chem. Toxicol., 46(11), S95 – S96 (2008).

    Article  CAS  PubMed  Google Scholar 

  68. S. Chouhan, K. Sharma and S. Guleria, Medicines, 4(58), 1 – 21 (2017).

    Google Scholar 

  69. E. Guzman and A. Lucia, Cosmetics, No. 8, 114 (2021).

    CAS  Google Scholar 

  70. N. A. Mahizan, S. K. Yang, C. L. Moo, et al., Molecules, 24(14), 2631 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. F. Nazzaro, F. Fratianni, L. D. Martino, et al., Pharmaceuticals, No. 6, 1451 – 1474 (2013).

    Google Scholar 

  72. R. Amorati, M. C. Foti and L. Valgimigli, J. Agric. Food Chem., No. 61, 10835 – 10847 (2013).

  73. Y. Yang, M. B. Isman and J.-H. Tak, Insects, No. 11, 474 (2020).

    Google Scholar 

  74. F. Francomano, A. Caruso, A. Barbarossa, et al., Appl. Sci., 9(24), 5420 (2019).

    Article  CAS  Google Scholar 

  75. S. Senapati, A. K. Mahanta, S. Kumar, et al., Signal Transduction Targeted Ther., No. 3, 7 (2018).

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Acknowledgments

The authors would like to acknowledge Universiti Sains Malaysia and Universiti Kuala Lumpur for providing the assistance and support to the present review study.

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Correspondence to Wen-Nee Tan.

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Tan, WN., Ali, R., Tong, WY. et al. Essential Oils from Traditional Medicinal Plants in Malaysia: A Review on Their Traditional Uses, Bioactive Constituents and Therapeutic Potential. Pharm Chem J 57, 703–711 (2023). https://doi.org/10.1007/s11094-023-02941-x

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