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Antioxidant Activity, Inhibition of No Production and Cytotoxicity of Chemical Compounds Isolated from Oxalis corniculata L.

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Five flavonoid compounds were isolated from ethyl acetate extract of the aerial part of Oxalis corniculata L. and identified as: 4′,5,7-trihydroxy-6-methoxyisoflavon (tectorigenin 1), 3′,5,7-trihydroxy-4′,5′,6-trimethoxyisoflavon (irigenin 2), 4′,5,7-trihydroxy-3′,6-dimethoxyisoflavon (iristectorigenin A 3), kaempferol-3,7-di-O-α-L-rhamnopyranosid (kaempferitrin 4), and kaempferol-3-O-α-L-rhamnopyranosyl-(1→2)-α-Larabinofuranosid (arapetaloside B 5). All the isolated compounds showed potential antioxidant effects in DPPH radical scavenging activity test with IC50 values in the range from 28.62 to 48.53 μg/mL, varied in following order: compound 1 > 3 > 2 > 5 > 4. The five phytochemicals produced inhibition of nitric oxide (NO) production, with IC50 values ranging from 18.6 to 39.5 μM. All isolated compounds exhibited cytotoxicity against HepG2, LU-1, MCF-7 and SK-Mel-2 cells using Sulforhodamine B assay, with IC50 values in the range ftom 12.32 to 39.88 μM.

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Authors and Affiliations

  1. Vietnam National University of Medicine and Pharmacy, Hanoi, Vietnam

    Loi Vu Duc, Mai Nguyen Thi, Duong Le Hong & Giang Le Huong

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  1. Loi Vu Duc
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  2. Mai Nguyen Thi
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  4. Giang Le Huong
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Correspondence to Loi Vu Duc.

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Duc, L.V., Thi, M.N., Le Hong, D. et al. Antioxidant Activity, Inhibition of No Production and Cytotoxicity of Chemical Compounds Isolated from Oxalis corniculata L.. Pharm Chem J 57, 388–394 (2023). https://doi.org/10.1007/s11094-023-02895-0

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