Three-step synthesis of 6-amino-3(H)-quinazolin-4-ones has been performed. Initially, the condensation of 3(H)-quinazolin-4-one was carried out in the presence of anthranilic acid and formamide in a 1:3 ratio. Then, hydrogen atom in state 6 of the resulting 3(H)-quinazolin-4-one was replaced by nitro group using a nitriding compound and 6-nitro-3(H)-quinazolin-4-one reduction was performed using SnCl2·2H2O as a reducing agent. Acylation reactions were accomplished on the synthesized 6-amino-3(H)-quinazolin-4-one. The structures of synthesized compounds were determined based on their IR and 1H NMR spectra. The obtained compounds were evaluated for antibacterial and antifungal activities by the agar disk diffusion test. The results indicated that 6-nitro-3(H)-quinazolin-4-one exhibited remarkable antibacterial activity against Bacillus subtilis, Staphylococcus aureus and Escherichia coli bacterial strains.
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Ziyadullaev, M., Karimov, R., Abdurazakhov, A. et al. Synthesis of 6-Substituted 3(H)-Quinazolin-4-Ones and Their Antimicrobial Activity. Pharm Chem J 57, 373–377 (2023). https://doi.org/10.1007/s11094-023-02892-3
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DOI: https://doi.org/10.1007/s11094-023-02892-3