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Current Trends in Steroid Chemistry

  • SEARCH FOR NEW DRUGS
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Pharmaceutical Chemistry Journal Aims and scope

Literature data over the past 10 years on the search for new drugs based on synthetic steroids are summarized and reviewed. Modern achievements in improving the effectiveness of steroid compounds are described. Methods for improving and modulating their pharmacological profile and biological activity are considered. The main attention is paid to the dependence of biological activity on chemical modification of the steroid scaffold or side chains. The role of compounds containing a steroid scaffold in the therapy of hormone-dependent tumors is highlighted.

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Authors and Affiliations

  1. Sechenov First Moscow State Medical University, Ministry of Health of Russia, 8/2 Trubetskaya St, Moscow, 119048, Russia

    M. N. Sokolov, V. V. Rozhkov & V. M. Trukhan

  2. Pirogov Russian National Research Medical University, Ministry of Health of Russia, 10/1 Ostrovityanova St, Moscow, 117997, Russia

    N. L. Shimanovskii

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  1. M. N. Sokolov
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  2. V. V. Rozhkov
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  3. V. M. Trukhan
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  4. N. L. Shimanovskii
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Correspondence to M. N. Sokolov.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 3, pp. 3 – 13, March, 2023.

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Sokolov, M.N., Rozhkov, V.V., Trukhan, V.M. et al. Current Trends in Steroid Chemistry. Pharm Chem J 57, 336–346 (2023). https://doi.org/10.1007/s11094-023-02887-0

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