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Polypill as a Personalized Dosage Form: Production Technology (Review)

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

Modern technologies for production of polypills used as a dosage form for personalized therapy are reviewed. Polypills can be in the form of multi-layer tablets or multi-particulate formulations [capsule with tablets, mini-tablets (micro-tablets), pellets (granules), powder]. Modern technologies for production of multi-layered tablets and multi-particulate formulations, dosing systems, and packaging developed for polypills are considered in detail. Polypills address the important issues of multidrug therapy such as physicochemical or pharmacological incompatibility of the components by separation of active pharmaceutical ingredients, controlled release, and personalization of the dosage form through reconfiguration and ensure patient adherence to therapy.

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Authors and Affiliations

  1. St. Petersburg State Chemical and Pharmaceutical University, Ministry of Health of the Russian Federation, 14-A Prof. Popova St, St. Petersburg, 197376, Russia

    K. M. Tserkovnaya, Yu. M. Kotsur, E. V. Flisyuk & I. A. Narkevich

Authors
  1. K. M. Tserkovnaya
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  2. Yu. M. Kotsur
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  3. E. V. Flisyuk
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  4. I. A. Narkevich
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Corresponding author

Correspondence to K. M. Tserkovnaya.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 1, pp. 43 – 51, January, 2023

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Tserkovnaya, K.M., Kotsur, Y.M., Flisyuk, E.V. et al. Polypill as a Personalized Dosage Form: Production Technology (Review). Pharm Chem J 57, 108–115 (2023). https://doi.org/10.1007/s11094-023-02857-6

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  • DOI: https://doi.org/10.1007/s11094-023-02857-6

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